high molecular weight kininogen


high mo·lec·u·lar weight ki·nin·o·gen (HMWK),

a plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein. Synonym(s): Fitzgerald factor, Flaujeac factor, Williams factor

high mo·lec·u·lar weight ki·nin·o·gen

(HMWK) (hī mŏ-lek'yū-lăr wāt ki-nin'ō-jen) A plasma protein of 110,000 molecular weight that normally exists in plasma in a 1:1 complex with prekallikrein. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to kallikrein.