Henoch-Schonlein purpura

purpura

[per´pu-rah] a hemorrhagic disease characterized by extravasation of blood into the tissues, under the skin, and through the mucous membranes, and producing spontaneous bruises, ecchymoses, and petechiae (small hemorrhagic spots) on the skin. (See plate in Dermatology Atlas.) When accompanied by a decrease in the circulating platelets, it is called thrombocytopenic purpura; when there is no decrease in the platelet count, it is called nonthrombocytopenic purpura. adj., adj purpu´ric.
There are two general types of thrombocytopenic purpura: primary or idiopathic, in which the cause is unknown, and secondary or symptomatic, which may be associated with exposure to drugs or other chemical agents, systemic diseases such as multiple myeloma and leukemia, diseases affecting the bone marrow or spleen, and infectious diseases such as rubella (German measles).Symptoms. The outward manifestations and laboratory findings of primary and secondary thrombocytopenic purpura are similar. There is evidence of bleeding under the skin, with easy bruising and the development of petechiae. In the acute form there may be bleeding from any of the body orifices, such as hematuria, nosebleed, vaginal bleeding, and bleeding gums. The count" >platelet count is below 100,000 per cubic millimeter of blood and may go as low as 10,000 per cubic millimeter (normal count is about 250,000 per cubic millimeter). The bleeding time is prolonged and clot retraction is poor. Coagulation time is normal.Treatment. Differential diagnosis is necessary to determine the type of purpura present and to eliminate the cause if it can be determined. General measures include protection of the patient from trauma, elective surgery, and tooth extractions, any one of which may lead to severe or even fatal hemorrhage. In the thrombocytopenic form, corticosteroids may be administered when the purpura is moderately severe and of short duration. Splenectomy is indicated when other, more conservative measures fail and is successful in a majority of cases. In some instances, especially in children, there may be spontaneous and permanent recovery from idiopathic purpura. (See Atlas 2, Part Q.)allergic purpura (anaphylactoid purpura) Henoch-Schönlein purpura.annular telangiectatic purpura a rare form in which pinpoint reddened lesions coalesce to form a ring-shaped or continuously linked pattern, commonly beginning in the lower extremities and becoming generalized. Called also Majocchi's disease.fibrinolytic purpura purpura associated with increased fibrinolytic activity of the blood.purpura ful´minans a form of nonthrombocytopenic purpura seen mainly in children, usually after an infectious disease, marked by fever, shock, anemia, and sudden, rapidly spreading symmetrical skin hemorrhages of the lower limbs, often associated with extensive intravascular thromboses and gangrene.purpura hemorrha´gica primary thrombocytopenic purpura.Henoch's purpura a type of Henoch-Schönlein purpura in which abdominal symptoms predominate.Henoch-Schönlein purpura a type of nonthrombocytopenic purpura, of unknown cause but thought to be due to a vasculitis; it is most often seen in children and is associated with clinical symptoms such as urticaria and erythema, arthritis and other joint diseases, gastrointestinal symptoms, and renal involvement. Called also Schönlein-Henoch purpura or syndrome and allergic or anaphylactoid purpura.idiopathic thrombocytopenic purpura thrombocytopenic purpura not directly associated with any definable systemic disease, although it often follows a systemic infection; the cause is thought to be an IgG immunoglobulin that acts as an antibody against platelets, causing ecchymoses, petechiae, and other bleeding. There are both acute and chronic forms: the acute form has a sudden onset, is more common in children, and usually resolves spontaneously within a few months; the chronic form has a slower onset, is more common in adults, and may be recurrent.nonthrombocytopenic purpura purpura without any decrease in the platelet count of the blood. In such cases the cause is either abnormal capillary fragility or a clotting factor deficiency.Schönlein purpura a type of Henoch-Schönlein purpura in which articular systems predominate; called also Schönlein's disease.Schönlein-Henoch purpura Henoch-Schönlein purpura.purpura seni´lis dark purplish red ecchymoses occurring on the forearms and backs of the hands in the elderly.thrombocytopenic purpura purpura associated with a decrease in the number of platelets in the blood; see purpura." >purpura.thrombotic thrombocytopenic purpura a form of microangiopathy" >thrombotic microangiopathy characterized by thrombocytopenia, hemolytic anemia, bizarre neurological manifestations, uremia (azotemia), fever, and thromboses in terminal arterioles and capillaries; some authorities consider it identical to the hemolytic uremic syndrome. Called also microangiopathic hemolytic anemia and Moschcowitz's disease.

He·noch-Schön·lein pur·pu·ra

(he'nok shĕrn'līn), an eruption of nonthrombocytopenic, palpable purpuric lesions due to dermal leukocytoclastic vasculitis with IgA in vessel walls associated with joint pain and swelling, colic, and passage of bloody stools, and occurring characteristically in young children; glomerulonephritis may occur during an initial episode or develop later. Synonym(s): anaphylactoid purpura (2) , Henoch purpura, Henoch-Schönlein syndrome, purpura rheumatica, Schönlein purpura, Schönlein-Henoch syndrome

Henoch-Schönlein purpura

Anaphylactoid purpura, vascular purpura Internal medicine An acquired form of small vessel vasculitis with IgA-dominant immune deposits affecting small vessels–arteries, capillaries, venules, typically of the skin, gut, and glomeruli, associated with arthralgia and/or arthritis; HSP is most common in younger Pts Clinical Red maculopapules on legs and buttocks, glomerulonephritis, abdominal pain ± infarction, diarrhea, fever, arthritis Lab IgA deposits in basement membrane of skin and glomerulus Treatment NSAIDs, aspirin, steroids–eg, prednisone, especially in Pts with major abdominal pain or kidney disease Prognosis Usually self limited. See Small vessel vasculitis, Systemic vasculitis.

He·noch-Schön·lein pur·pu·ra

(hen'awk shĕrn'līn pŭr'pyŭr-ă) An eruption of nonthrombocytopenic purpuric lesions due to dermal leukocytoclastic vasculitis with IgA in vessel walls associated with joint pain and swelling, colic, and passage of bloody stools, and occurring characteristically in young children; glomerulonephritis may occur during an initial episode or develop later.
Synonym(s): anaphylactoid purpura (2) , Henoch purpura, Schönlein purpura.

Henoch-Schönlein purpura

(hen'ok-shan'lin) [Eduard H. Henoch, Ger. pediatrician, 1820–1910; Johann Lukas Schönlein, Ger. physician, 1793–1864]

HENOCH-SCH~Ouml`NLEIN PURPURA: Characteristic rash on the buttocksA form of small vessel vasculitis of unknown cause that affects children, esp. between the ages of 3 and 5, more often than adults. It is marked by a purpuric rash on the buttocks and legs, and, in some patients, abdominal pain or gastrointestinal bleeding, polyarticular joint disease, and renal involvement (e.g., glomerulonephritis). The illness usually lasts about 2 weeks before resolving spontaneously. In some instances (more commonly in adults than in children) renal failure can complicate the illness. Synonym: anaphylactoid purpura See: illustration

Treatment

Joint symptoms respond to rest and administration of nonsteroidal anti-inflammatory drugs. Corticosteroid drugs, such as prednisone, are used to treat patients with severe gastrointestinal or renal involvement. Hemodialysis is used to support patients who develop chronic renal failure.

Henoch,

Eduard Heinrich, German pediatrician, 1820-1910. Henoch chorea - a disorder in which sudden spasmodic coordinated movements of certain muscles or groups of physiologically related muscles occur at irregular intervals. Synonym(s): spasmodic ticHenoch purpura - Synonym(s): Henoch-Schönlein purpuraHenoch-Schönlein purpura - an eruption of nonthrombocytopenic purpuric lesions due to dermal leukocytoclastic vasculitis. Synonym(s): acute vascular purpura; anaphylactoid purpura; Henoch purpura; Henoch-Schönlein purpura; Henoch-Schönlein syndrome; purpura nervosa; purpura rheumatica; Schönlein disease; Schönlein purpuraHenoch-Schönlein syndrome - Synonym(s): Henoch-Schönlein purpuraSchönlein-Henoch syndrome - Synonym(s): Henoch-Schönlein purpura

Schönlein,

Johann Lukas, German physician, 1793-1864. Henoch-Schönlein purpura - see under HenochHenoch-Schönlein syndrome - Synonym(s): Henoch-Schönlein purpuraSchönlein disease - Synonym(s): Henoch-Schönlein purpuraSchönlein purpura - Synonym(s): Henoch-Schönlein purpuraSchönlein-Henoch syndrome - Synonym(s): Henoch-Schönlein purpura

He·noch-Schön·lein pur·pu·ra

(hen'awk shĕrn'līn pŭr'pyŭr-ă) Eruption of nonthrombocytopenic, palpable, purpuric lesions due to dermal leukocytoclastic vasculitis with IgA in vessel walls associated with joint pain and swelling, colic, and bloody stools; occurring characteristically in young children.
Synonym(s): anaphylactoid purpura (2) .

单词	henoch-schonlein purpura
释义	DictionarySeepurpura Henoch-Schonlein purpura purpura [per´pu-rah] a hemorrhagic disease characterized by extravasation of blood into the tissues, under the skin, and through the mucous membranes, and producing spontaneous bruises, ecchymoses, and petechiae (small hemorrhagic spots) on the skin. (See plate in Dermatology Atlas.) When accompanied by a decrease in the circulating platelets, it is called thrombocytopenic purpura; when there is no decrease in the platelet count, it is called nonthrombocytopenic purpura. adj., adj purpu´ric. There are two general types of thrombocytopenic purpura: primary or idiopathic, in which the cause is unknown, and secondary or symptomatic, which may be associated with exposure to drugs or other chemical agents, systemic diseases such as multiple myeloma and leukemia, diseases affecting the bone marrow or spleen, and infectious diseases such as rubella (German measles).Symptoms. The outward manifestations and laboratory findings of primary and secondary thrombocytopenic purpura are similar. There is evidence of bleeding under the skin, with easy bruising and the development of petechiae. In the acute form there may be bleeding from any of the body orifices, such as hematuria, nosebleed, vaginal bleeding, and bleeding gums. The count" >platelet count is below 100,000 per cubic millimeter of blood and may go as low as 10,000 per cubic millimeter (normal count is about 250,000 per cubic millimeter). The bleeding time is prolonged and clot retraction is poor. Coagulation time is normal.Treatment. Differential diagnosis is necessary to determine the type of purpura present and to eliminate the cause if it can be determined. General measures include protection of the patient from trauma, elective surgery, and tooth extractions, any one of which may lead to severe or even fatal hemorrhage. In the thrombocytopenic form, corticosteroids may be administered when the purpura is moderately severe and of short duration. Splenectomy is indicated when other, more conservative measures fail and is successful in a majority of cases. In some instances, especially in children, there may be spontaneous and permanent recovery from idiopathic purpura. (See Atlas 2, Part Q.)allergic purpura (anaphylactoid purpura) Henoch-Schönlein purpura.annular telangiectatic purpura a rare form in which pinpoint reddened lesions coalesce to form a ring-shaped or continuously linked pattern, commonly beginning in the lower extremities and becoming generalized. Called also Majocchi's disease.fibrinolytic purpura purpura associated with increased fibrinolytic activity of the blood.purpura ful´minans a form of nonthrombocytopenic purpura seen mainly in children, usually after an infectious disease, marked by fever, shock, anemia, and sudden, rapidly spreading symmetrical skin hemorrhages of the lower limbs, often associated with extensive intravascular thromboses and gangrene.purpura hemorrha´gica primary thrombocytopenic purpura.Henoch's purpura a type of Henoch-Schönlein purpura in which abdominal symptoms predominate.Henoch-Schönlein purpura a type of nonthrombocytopenic purpura, of unknown cause but thought to be due to a vasculitis; it is most often seen in children and is associated with clinical symptoms such as urticaria and erythema, arthritis and other joint diseases, gastrointestinal symptoms, and renal involvement. Called also Schönlein-Henoch purpura or syndrome and allergic or anaphylactoid purpura.idiopathic thrombocytopenic purpura thrombocytopenic purpura not directly associated with any definable systemic disease, although it often follows a systemic infection; the cause is thought to be an IgG immunoglobulin that acts as an antibody against platelets, causing ecchymoses, petechiae, and other bleeding. There are both acute and chronic forms: the acute form has a sudden onset, is more common in children, and usually resolves spontaneously within a few months; the chronic form has a slower onset, is more common in adults, and may be recurrent.nonthrombocytopenic purpura purpura without any decrease in the platelet count of the blood. In such cases the cause is either abnormal capillary fragility or a clotting factor deficiency.Schönlein purpura a type of Henoch-Schönlein purpura in which articular systems predominate; called also Schönlein's disease.Schönlein-Henoch purpura Henoch-Schönlein purpura.purpura seni´lis dark purplish red ecchymoses occurring on the forearms and backs of the hands in the elderly.thrombocytopenic purpura purpura associated with a decrease in the number of platelets in the blood; see purpura." >purpura.thrombotic thrombocytopenic purpura a form of microangiopathy" >thrombotic microangiopathy characterized by thrombocytopenia, hemolytic anemia, bizarre neurological manifestations, uremia (azotemia), fever, and thromboses in terminal arterioles and capillaries; some authorities consider it identical to the hemolytic uremic syndrome. Called also microangiopathic hemolytic anemia and Moschcowitz's disease. He·noch-Schön·lein pur·pu·ra (he'nok shĕrn'līn), an eruption of nonthrombocytopenic, palpable purpuric lesions due to dermal leukocytoclastic vasculitis with IgA in vessel walls associated with joint pain and swelling, colic, and passage of bloody stools, and occurring characteristically in young children; glomerulonephritis may occur during an initial episode or develop later. Synonym(s): anaphylactoid purpura (2) , Henoch purpura, Henoch-Schönlein syndrome, purpura rheumatica, Schönlein purpura, Schönlein-Henoch syndrome Henoch-Schönlein purpura Anaphylactoid purpura, vascular purpura Internal medicine An acquired form of small vessel vasculitis with IgA-dominant immune deposits affecting small vessels–arteries, capillaries, venules, typically of the skin, gut, and glomeruli, associated with arthralgia and/or arthritis; HSP is most common in younger Pts Clinical Red maculopapules on legs and buttocks, glomerulonephritis, abdominal pain ± infarction, diarrhea, fever, arthritis Lab IgA deposits in basement membrane of skin and glomerulus Treatment NSAIDs, aspirin, steroids–eg, prednisone, especially in Pts with major abdominal pain or kidney disease Prognosis Usually self limited. See Small vessel vasculitis, Systemic vasculitis. He·noch-Schön·lein pur·pu·ra (hen'awk shĕrn'līn pŭr'pyŭr-ă) An eruption of nonthrombocytopenic purpuric lesions due to dermal leukocytoclastic vasculitis with IgA in vessel walls associated with joint pain and swelling, colic, and passage of bloody stools, and occurring characteristically in young children; glomerulonephritis may occur during an initial episode or develop later. Synonym(s): anaphylactoid purpura (2) , Henoch purpura, Schönlein purpura. Henoch-Schönlein purpura (hen'ok-shan'lin) [Eduard H. Henoch, Ger. pediatrician, 1820–1910; Johann Lukas Schönlein, Ger. physician, 1793–1864] HENOCH-SCH~Ouml`NLEIN PURPURA: Characteristic rash on the buttocksA form of small vessel vasculitis of unknown cause that affects children, esp. between the ages of 3 and 5, more often than adults. It is marked by a purpuric rash on the buttocks and legs, and, in some patients, abdominal pain or gastrointestinal bleeding, polyarticular joint disease, and renal involvement (e.g., glomerulonephritis). The illness usually lasts about 2 weeks before resolving spontaneously. In some instances (more commonly in adults than in children) renal failure can complicate the illness. Synonym: anaphylactoid purpura See: illustration Treatment Joint symptoms respond to rest and administration of nonsteroidal anti-inflammatory drugs. Corticosteroid drugs, such as prednisone, are used to treat patients with severe gastrointestinal or renal involvement. Hemodialysis is used to support patients who develop chronic renal failure. Henoch, Eduard Heinrich, German pediatrician, 1820-1910. Henoch chorea - a disorder in which sudden spasmodic coordinated movements of certain muscles or groups of physiologically related muscles occur at irregular intervals. Synonym(s): spasmodic ticHenoch purpura - Synonym(s): Henoch-Schönlein purpuraHenoch-Schönlein purpura - an eruption of nonthrombocytopenic purpuric lesions due to dermal leukocytoclastic vasculitis. Synonym(s): acute vascular purpura; anaphylactoid purpura; Henoch purpura; Henoch-Schönlein purpura; Henoch-Schönlein syndrome; purpura nervosa; purpura rheumatica; Schönlein disease; Schönlein purpuraHenoch-Schönlein syndrome - Synonym(s): Henoch-Schönlein purpuraSchönlein-Henoch syndrome - Synonym(s): Henoch-Schönlein purpura Schönlein, Johann Lukas, German physician, 1793-1864. Henoch-Schönlein purpura - see under HenochHenoch-Schönlein syndrome - Synonym(s): Henoch-Schönlein purpuraSchönlein disease - Synonym(s): Henoch-Schönlein purpuraSchönlein purpura - Synonym(s): Henoch-Schönlein purpuraSchönlein-Henoch syndrome - Synonym(s): Henoch-Schönlein purpura He·noch-Schön·lein pur·pu·ra (hen'awk shĕrn'līn pŭr'pyŭr-ă) Eruption of nonthrombocytopenic, palpable, purpuric lesions due to dermal leukocytoclastic vasculitis with IgA in vessel walls associated with joint pain and swelling, colic, and bloody stools; occurring characteristically in young children. Synonym(s): anaphylactoid purpura (2) .
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