Henderson-Hasselbalch equation

equation

[e-kwa´zhun] an expression of equality between two parts.Henderson-Hasselbalch equation a formula for calculating the pH of a buffer solution such as blood plasma, pH = pK_a + log [BA/HA]; [HA] is the concentration of a free weak acid; [BA] the concentration of the ionized form of this acid; pK_a the acid dissociation constant, a measure of the ionization equilibrium of the acid.

Hen·der·son-Has·sel·balch e·qua·tion

(hen'dĕr-sŏn hahs'ĕl-bawlk), a formula relating the pH value of a solution to the pK_a value of the acid in the solution and the ratio of the acid and the conjugate base concentrations: pH = pK_a + log([A^-]/[HA]), where [A^-] is the concentration of the conjugate base and [HA] is the concentration of the protonated acid. For the bicarbonate buffer system in blood, pH = pK' + log([HCO₃^-]/[CO₂]). The value of pK' for blood plasma is 6.10 and includes the first dissociation constant of H₂CO₃, the relation between [H₂CO₃] and [CO₂], and other corrections. The partial pressure of CO₂ multiplied by its solubility in plasma at 38°C (0.0301 mM/mm Hg) is commonly substituted for [CO₂]; for example, when the plasma bicarbonate concentration is 24 mEq/L and the P_CO2 is 40 mm Hg, the pH value is 6.10 + log(24/0.0301 × 40) = 7.40. [Lawrence J. Henderson, Karl Hasselbalch]

Hen·der·son-Has·sel·balch e·qua·tion

(hen'dĕr-sŏn hahs'ĕl-bawlk ĕ-kwā'zhŭn) A formula relating the pH value of a solution to the pK_a value of the acid in the solution and the ratio of the acid and the conjugate base concentrations: pH = pK_a + log ([A^-]/[HA]) where [A^-] is the concentration of the conjugate base and [HA] is the concentration of the protonated acid. [Lawrence J. Henderson, Karl Hasselbalch]

Hasselbalch,

Karl, Danish biochemist and physician, 1874-1962. Henderson-Hasselbalch equation - see under Henderson

Henderson,

Lawrence J., U.S. biochemist, 1879-1942. Henderson-Hasselbalch equation - a formula relating the pH value of a solution to the value of the acid in the solution and the ratio of the acid and the conjugate base concentrations.

单词	henderson-hasselbalch equation
释义	DictionarySeeequation Henderson-Hasselbalch equation equation [e-kwa´zhun] an expression of equality between two parts.Henderson-Hasselbalch equation a formula for calculating the pH of a buffer solution such as blood plasma, pH = pK_a + log [BA/HA]; [HA] is the concentration of a free weak acid; [BA] the concentration of the ionized form of this acid; pK_a the acid dissociation constant, a measure of the ionization equilibrium of the acid. Hen·der·son-Has·sel·balch e·qua·tion (hen'dĕr-sŏn hahs'ĕl-bawlk), a formula relating the pH value of a solution to the pK_a value of the acid in the solution and the ratio of the acid and the conjugate base concentrations: pH = pK_a + log([A^-]/[HA]), where [A^-] is the concentration of the conjugate base and [HA] is the concentration of the protonated acid. For the bicarbonate buffer system in blood, pH = pK' + log([HCO₃^-]/[CO₂]). The value of pK' for blood plasma is 6.10 and includes the first dissociation constant of H₂CO₃, the relation between [H₂CO₃] and [CO₂], and other corrections. The partial pressure of CO₂ multiplied by its solubility in plasma at 38°C (0.0301 mM/mm Hg) is commonly substituted for [CO₂]; for example, when the plasma bicarbonate concentration is 24 mEq/L and the P_CO2 is 40 mm Hg, the pH value is 6.10 + log(24/0.0301 × 40) = 7.40. [Lawrence J. Henderson, Karl Hasselbalch] Hen·der·son-Has·sel·balch e·qua·tion (hen'dĕr-sŏn hahs'ĕl-bawlk ĕ-kwā'zhŭn) A formula relating the pH value of a solution to the pK_a value of the acid in the solution and the ratio of the acid and the conjugate base concentrations: pH = pK_a + log ([A^-]/[HA]) where [A^-] is the concentration of the conjugate base and [HA] is the concentration of the protonated acid. [Lawrence J. Henderson, Karl Hasselbalch] Hasselbalch, Karl, Danish biochemist and physician, 1874-1962. Henderson-Hasselbalch equation - see under Henderson Henderson, Lawrence J., U.S. biochemist, 1879-1942. Henderson-Hasselbalch equation - a formula relating the pH value of a solution to the value of the acid in the solution and the ratio of the acid and the conjugate base concentrations.
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