countable/uncountable something that makes one thing or person not the same as another thing or personcultural/social/political differences
difference between: What’s the difference between these two computers?
difference in: There’s a big difference in the attitudes of town and country people.
slight/subtle/minor differences: There are subtle differences in their arrangement of the music.
significant/marked/major difference: the significant difference in sound quality between CDs and records
crucial/essential/fundamental difference: The fundamental difference between John and Jake is their attitudes to money.