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单词 antimetabolite
释义

antimetabolite

noun

an·​ti·​me·​tab·​o·​lite
ˌan-tē-mə-ˈta-bə-ˌlīt,
ˌan-ˌtī- How to pronounce antimetabolite (audio)
: a substance that is structurally similar to a metabolite (such as a coenzyme) and that serves to inhibit a particular cellular function (such as DNA synthesis) by interfering with or blocking the metaboliteʼs action
From the start [Gertrude] Elion concentrated her research on using purine and pyrimidine antimetabolites to interfere with the synthesis of nucleic acids … Mairin Brennan
antimetabolic
ˌan-tē-ˌme-tə-ˈbä-lik How to pronounce antimetabolite (audio)
ˌan-tī-
adjective
a drug with antimetabolic action

Word History

First Known Use

1945, in the meaning defined above

Medical Definition

antimetabolite

noun

an·​ti·​me·​tab·​o·​lite ˌant-i-mə-ˈtab-ə-ˌlīt, ˌan-ˌtī- How to pronounce antimetabolite (audio)
: a substance that is structurally similar to a metabolite (as a coenzyme) and that serves to inhibit a particular cellular function (as DNA synthesis) by interfering with or blocking the metaboliteʼs action
Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies. Jane E. Brody
antimetabolite therapy
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更新时间:2024/11/11 0:56:13