anneal

verb

an·neal ə-ˈnēl How to pronounce anneal (audio)

annealed; annealing; anneals

transitive verb

: to heat and then cool (a material, such as steel or glass) usually for softening and making less brittle

Each bar, with its intricate twists, bevels and turns, had to be shaped individually. This shaping made some parts of the bars brittle … . To restore their flexibility, all the bars had to be annealed by heating, and then rapidly cooling them.

Ivars Peterson

also : to cool slowly usually in a furnace

: to cause two complementary strands of nucleic acid (such as DNA or RNA) to join by hydrogen bonding

During repair of DNA double-strand breaks, cells must accurately anneal broken strands …

Seiji N. Sugiman-Marangos et al.

also : to induce the binding of a genetic primer (see primer entry 2 sense 3) to a complementary single-stranded nucleic acid by slowly cooling single strands obtained from the heating and separation of double-stranded DNA or RNA

The primers are annealed to the single strands when the local temperature is reduced to between 50 and 65 C.

Andrew J. DeMello

During PCR, fragments are heated so they will separate into single strands. A short nucleotide sequence called a primer is then annealed to each original template.

George M. Church

: strengthen, toughen

intransitive verb

: to pair with a complementary strand of nucleic acid

A microRNA molecule can anneal to a messenger RNA (mRNA) containing a nucleotide sequence that complements the sequence of the microRNA …

Carlo M. Croce

also : to bind to a complementary single-stranded nucleic acid during a process of heating and cooling

Site-specific primers, designed to complement the base pairs of the DNA region flanking the target, anneal to these regions.

Norman Arnhelm and Corey H. Levenson

: strengthen, toughen

Mildred at least, is capable of love. In Veda, love has been annealed to a hard diamond of ambition.

Stephen King

Did you know?

Anneal Has a Fiery History

If you were looking for a saying to apply to the word anneal, it might be "everything old is new again." The word was originally associated with one of the oldest technologies of humankind: fire. It derives from the Old English word onǣlan, which was formed from the Old English root āl, meaning "fire." In its earliest known uses, anneal meant simply "to set on fire." That sense has become obsolete, however, and nowadays anneal is associated with metalworking and glasswork as well as a much more recent technological development. As addressed in sense 3 of the definition, it has come to be used in the context of DNA research, in reference to the heating and cooling of double-stranded nucleic acid.

Example Sentences

Recent Examples on the Web For hybrid algorithms, the back and forth between classical and annealing worlds means regular communications with the D-Wave hardware, which helped motivate the company to try to reduce the latency of those communications.

John Timmer, Ars Technica, 1 Oct. 2019 Further Reading D-Wave announces the next generation of its quantum annealerThe other challenge annealing faces is that classical algorithms are constantly improving.

John Timmer, Ars Technica, 1 Oct. 2019 Solutions are downhill One way to compute a solution to a problem is called annealing.

Chris Lee, Ars Technica, 13 June 2019 The slow cooling of the glass allows it to anneal, relieving internal stresses and improving durability.

Jay Bennett, Popular Mechanics, 14 Feb. 2018 Before and after the Eagles’ organized team activities last spring, Nelson Agholor retreated to his hometown for a series of training sessions with an old friend and mentor that would anneal his mind as much as his body.

Mike Sielski, Philly.com, 8 Oct. 2017 To make the object, the copper was alternately hammered and annealed—a process of heating metal and allowing it to cool slowly.

Brigit Katz, Smithsonian, 12 June 2017 See More

Medical Definition

anneal

transitive verb

an·neal ə-ˈnē(ə)l How to pronounce anneal (audio)

: to heat and then cool (as steel or glass) usually for softening and making less brittle

: to heat and then cool (double-stranded nucleic acid) in order to separate strands and induce combination at lower temperatures especially with complementary strands

intransitive verb

: to be capable of combining with complementary nucleic acid by a process of heating and cooling

some bacterial nucleic acid anneals well with eukaryotic DNA

annealed 1 of 2

adjective

as in tempered

Synonyms & Similar Words

Relevance

tempered
seasoned
fortified
robust
virile
sound
strapping
hale
fit
healthy
husky
durable
muscular
hardened
lusty
stable
brawny
permanent
toughened
flourishing
prospering
red-blooded
immortal
enduring
resilient
lasting
imperishable
able-bodied
staying
unyielding
leathery
inured
everlasting
flinty
thriving
tenacious
hardy
sturdy
staunch
stanch
vigorous
stout
rugged
stalwart
cast-iron
tough
strong
hard-bitten
hard

Antonyms & Near Antonyms

soft
weak
worn
weakened
enfeebled
delicate
exhausted
tender
emasculated
wasted
diseased
nonhardy
fragile
enervated
debilitated
unsound
incapacitated
crippled
susceptible
infirm
yielding
sensitive
vulnerable
sapped
frail
worn-out
transient
resistless
puny
temporary
perishable
mortal
run-down
unresistant

annealed

2 of 2

verb

past tense of anneal

as in hardened

to make stronger (as through hardship) She was annealed by the tragedies of her childhood.

Synonyms & Similar Words

hardened
strengthened
tempered
reinforced
fortified
adjusted
toughened
steeled
adapted
inured
braced
indurated
acclimated
acclimatized
vitalized
seasoned
invigorated
enforced
immunized
supported
conditioned
bolstered
trained
buttressed
reenforced
habituated
accustomed
forearmed
boosted
naturalized
broke in
propped (up)
limbered (up)

Antonyms & Near Antonyms

exhausted
weakened
sensitized
enfeebled
sapped
softened
enervated
crippled
incapacitated
debilitated
hamstrung

单词	annealed
释义	anneal verb an·neal ə-ˈnēl annealed; annealing; anneals transitive verb 1 a : to heat and then cool (a material, such as steel or glass) usually for softening and making less brittle Each bar, with its intricate twists, bevels and turns, had to be shaped individually. This shaping made some parts of the bars brittle … . To restore their flexibility, all the bars had to be annealed by heating, and then rapidly cooling them. Ivars Peterson also : to cool slowly usually in a furnace b : to cause two complementary strands of nucleic acid (such as DNA or RNA) to join by hydrogen bonding During repair of DNA double-strand breaks, cells must accurately anneal broken strands … Seiji N. Sugiman-Marangos et al. also : to induce the binding of a genetic primer (see primer entry 2 sense 3) to a complementary single-stranded nucleic acid by slowly cooling single strands obtained from the heating and separation of double-stranded DNA or RNA The primers are annealed to the single strands when the local temperature is reduced to between 50 and 65 C. Andrew J. DeMello During PCR, fragments are heated so they will separate into single strands. A short nucleotide sequence called a primer is then annealed to each original template. George M. Church 2 : strengthen, toughen intransitive verb 1 : to pair with a complementary strand of nucleic acid A microRNA molecule can anneal to a messenger RNA (mRNA) containing a nucleotide sequence that complements the sequence of the microRNA … Carlo M. Croce also : to bind to a complementary single-stranded nucleic acid during a process of heating and cooling Site-specific primers, designed to complement the base pairs of the DNA region flanking the target, anneal to these regions. Norman Arnhelm and Corey H. Levenson 2 : strengthen, toughen Mildred at least, is capable of love. In Veda, love has been annealed to a hard diamond of ambition. Stephen King Did you know? Anneal Has a Fiery History If you were looking for a saying to apply to the word anneal, it might be "everything old is new again." The word was originally associated with one of the oldest technologies of humankind: fire. It derives from the Old English word onǣlan, which was formed from the Old English root āl, meaning "fire." In its earliest known uses, anneal meant simply "to set on fire." That sense has become obsolete, however, and nowadays anneal is associated with metalworking and glasswork as well as a much more recent technological development. As addressed in sense 3 of the definition, it has come to be used in the context of DNA research, in reference to the heating and cooling of double-stranded nucleic acid. Example Sentences Recent Examples on the Web For hybrid algorithms, the back and forth between classical and annealing worlds means regular communications with the D-Wave hardware, which helped motivate the company to try to reduce the latency of those communications. John Timmer, Ars Technica, 1 Oct. 2019 Further Reading D-Wave announces the next generation of its quantum annealerThe other challenge annealing faces is that classical algorithms are constantly improving. John Timmer, Ars Technica, 1 Oct. 2019 Solutions are downhill One way to compute a solution to a problem is called annealing. Chris Lee, Ars Technica, 13 June 2019 The slow cooling of the glass allows it to anneal, relieving internal stresses and improving durability. Jay Bennett, Popular Mechanics, 14 Feb. 2018 Before and after the Eagles’ organized team activities last spring, Nelson Agholor retreated to his hometown for a series of training sessions with an old friend and mentor that would anneal his mind as much as his body. Mike Sielski, Philly.com, 8 Oct. 2017 To make the object, the copper was alternately hammered and annealed—a process of heating metal and allowing it to cool slowly. Brigit Katz, Smithsonian, 12 June 2017 See More Word History Etymology Middle English anelen to set on fire, from Old English onǣlan, from on + ǣlan to set on fire, burn, from āl fire; akin to Old English ǣled fire, Old Norse eldr First Known Use 1664, in the meaning defined at transitive sense 1a Kids Definition anneal verb an·neal ə-ˈnēl annealed; annealing : to heat (as glass or steel) and then cool so as to toughen and make less brittle Medical Definition anneal transitive verb an·neal ə-ˈnē(ə)l 1 : to heat and then cool (as steel or glass) usually for softening and making less brittle 2 : to heat and then cool (double-stranded nucleic acid) in order to separate strands and induce combination at lower temperatures especially with complementary strands intransitive verb : to be capable of combining with complementary nucleic acid by a process of heating and cooling some bacterial nucleic acid anneals well with eukaryotic DNA annealed 1 of 2 adjective as in tempered Synonyms & Similar Words Relevance tempered seasoned fortified robust virile sound strapping hale fit healthy husky durable muscular hardened lusty stable brawny permanent toughened flourishing prospering red-blooded immortal enduring resilient lasting imperishable able-bodied staying unyielding leathery inured everlasting flinty thriving tenacious hardy sturdy staunch stanch vigorous stout rugged stalwart cast-iron tough strong hard-bitten hard Antonyms & Near Antonyms soft weak worn weakened enfeebled delicate exhausted tender emasculated wasted diseased nonhardy fragile enervated debilitated unsound incapacitated crippled susceptible infirm yielding sensitive vulnerable sapped frail worn-out transient resistless puny temporary perishable mortal run-down unresistant See More annealed 2 of 2 verb past tense of anneal as in hardened to make stronger (as through hardship) She was annealed by the tragedies of her childhood. Synonyms & Similar Words hardened strengthened tempered reinforced fortified adjusted toughened steeled adapted inured braced indurated acclimated acclimatized vitalized seasoned invigorated enforced immunized supported conditioned bolstered trained buttressed reenforced habituated accustomed forearmed boosted naturalized broke in propped (up) limbered (up) Antonyms & Near Antonyms exhausted weakened sensitized enfeebled sapped softened enervated crippled incapacitated debilitated hamstrung See More
随便看	noncasual noncausal nonce nonce word noncelebration noncelebrations noncelebrities noncelebrity noncellular noncellulosic noncentral noncentric noncertified nonces nonchalance nonchalances nonchalant nonchalantly nonchalantness noncharacter noncharacters aediles aedileships aedility aedine

anneal

verb

Did you know?

Example Sentences

Word History

Kids Definition

verb

Medical Definition

transitive verb

adjective

verb