单词	tumor suppressor gene
释义	tumor suppressor gene noun : any of a class of genes (such as p53) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation Word History First Known Use 1985, in the meaning defined above Medical Definition tumor suppressor gene noun variants or tumor-suppressor gene : any of a class of genes (as p53 and APC) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation In some cases [of cancer], growth-inhibiting genes called tumor suppressor genes are damaged, allowing cells to proliferate unchecked. Faye Flam, The Philadelphia Inquirer In most human-cancer cells, there are multiple mutations—some that activate oncogenes and some that silence tumor-suppressor genes. Robert A. Weinberg and Anthony L. Komaroff, Newsweek called also anti-oncogene
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