单词	tumor necrosis factor
释义	tumor necrosis factor noun : a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins and that mediates inflammation and induces the destruction of some tumor cells and the activation of white blood cells Example Sentences Recent Examples on the Web One protein that stood out in the study was tumor necrosis factor alpha, which is made by the immune system to regulate inflammation. Sandee Lamotte, CNN, 5 Apr. 2022 The new Boxed Warning for JAK inhibitors also comes with the recommendation that doctors only approve them if patients haven't responded to, or cannot tolerate, other medications known as tumor necrosis factor (TNF) blockers. Korin Miller, Health.com, 8 Feb. 2022 For example, your doctor might suggest an anti-tumor necrosis factor drug that blocks a protein called TNF-alpha that promotes inflammation. Jennifer Larson, SELF, 3 Nov. 2021 The other is the pathway that triggers inflammation through proinflammatory cytokines like tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-8 (IL-8). William A. Haseltine, Forbes, 1 Nov. 2021 Several targeted therapies focus on a particularly powerful cytokine called tumor necrosis factor, or TNF. Marla Broadfoot, Scientific American, 1 Sep. 2021 Furthermore, the agency has limited the drug’s use to patients who’ve tried but failed on at least one tumor necrosis factor inhibitor. Trefis Team, Forbes, 7 Sep. 2021 These prevent the tumor necrosis factor protein from binding to its corresponding receptors and causing inflammation8. Stephanie Watso, SELF, 27 Aug. 2021 Infliximab is an antibody given as a single infusion that blocks tumor necrosis factor alpha, a pivotal signaling molecule in the immune system, and is used to treat autoimmune diseases such as rheumatoid arthritis and inflammatory bowel disease. Kai Kupferschmidt, Science | AAAS, 5 Aug. 2021 See More Word History First Known Use 1975, in the meaning defined above Medical Definition tumor necrosis factor noun : a protein that is produced chiefly by monocytes and macrophages in response especially to endotoxins, that mediates inflammation, and that induces the destruction of some tumor cells and the activation of white blood cells —abbreviation TNF
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