单词	topoisomerase
释义	topoisomerase noun topo·​isom·​er·​ase ˌtō-pō-ī-ˈsä-mə-ˌrās  -ˌrāz : any of a class of enzymes that reduce supercoiling in DNA by breaking and rejoining one or both strands of the DNA molecule Example Sentences Recent Examples on the Web When things start getting too tightly wound, topoisomerase cuts the DNA strand, unwinds it, and reattaches it with a bit more slack. Cathleen O'grady, Ars Technica, 15 Nov. 2018 But while gonorrhea has been evolving ways to stop ciprofloxacin from getting in the way of topoisomerase, those strategies don’t work on the new drug. Cathleen O'grady, Ars Technica, 15 Nov. 2018 When things start getting too tightly wound, topoisomerase cuts the DNA strand, unwinds it, and reattaches it with a bit more slack. Cathleen O'grady, Ars Technica, 15 Nov. 2018 Word History Etymology top- + isomerase First Known Use 1980, in the meaning defined above Medical Definition topoisomerase noun topo·​isom·​er·​ase ˌtō-pō-ī-ˈsäm-ə-ˌrās, -ˌrāz  : any of a class of enzymes that reduce supercoiling in DNA by breaking and rejoining one or both strands of the DNA molecule
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