tissue plasminogen activator
noun
: a clot-dissolving enzyme with an affinity for fibrin that is produced naturally in blood vessel linings and is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and reduce neurological damage following ischemic stroke —abbreviation TPA
Example Sentences
Recent Examples on the Web To facilitate protein expression of the RBD antigen, a CMV promoter and human tissue plasminogen activator (tPA) were also inserted, as shown in the figure below. 
William A. Haseltine, Forbes, 31 Jan. 2022 The procedure was now too risky and he was given intravenous tissue plasminogen activators (TPA), a treatment used to help dissolve blood clots. Hannah Drown, cleveland, 31 Oct. 2019 To qualify, hospitals must meet quality measures developed to reduce the time between the patient’s arrival at the hospital and treatment with the clot-buster tissue plasminogen activator, or tPA. baltimoresun.com/maryland/carroll, 19 Aug. 2019 The drug, known as tissue plasminogen activator (tPA), is a potent blood thinner and was approved as an effective clot-busting treatment by the Food and Drug Administration in 1996. Kevin Sheth, Washington Post, 8 Apr. 2018 For stroke, tissue plasminogen activator (tPA) must be administered within three hours to dissolve blood clots that may be blocking blood flow to the brain. Bryant Stamford, The Courier-Journal, 29 Mar. 2018 To qualify for the Target: Stroke Honor Roll, hospitals must meet quality measures developed to reduce the time between the patient's arrival at the hospital and treatment with the clot-busting agent called tissue plasminogen activator, or tPA. Houston Chronicle, 31 Oct. 2017 See More
William A. Haseltine, Forbes, 31 Jan. 2022 The procedure was now too risky and he was given intravenous tissue plasminogen activators (TPA), a treatment used to help dissolve blood clots. Hannah Drown, cleveland, 31 Oct. 2019 To qualify, hospitals must meet quality measures developed to reduce the time between the patient’s arrival at the hospital and treatment with the clot-buster tissue plasminogen activator, or tPA. baltimoresun.com/maryland/carroll, 19 Aug. 2019 The drug, known as tissue plasminogen activator (tPA), is a potent blood thinner and was approved as an effective clot-busting treatment by the Food and Drug Administration in 1996. Kevin Sheth, Washington Post, 8 Apr. 2018 For stroke, tissue plasminogen activator (tPA) must be administered within three hours to dissolve blood clots that may be blocking blood flow to the brain. Bryant Stamford, The Courier-Journal, 29 Mar. 2018 To qualify for the Target: Stroke Honor Roll, hospitals must meet quality measures developed to reduce the time between the patient's arrival at the hospital and treatment with the clot-busting agent called tissue plasminogen activator, or tPA. Houston Chronicle, 31 Oct. 2017 See More Word History
First Known Use
1981, in the meaning defined above
Medical Definition
tissue plasminogen activator
noun
: a clot-dissolving enzyme that has an affinity for fibrin, that catalyzes the conversion of plasminogen to plasmin, that is produced naturally in blood vessel linings, and that is used in a genetically engineered form to prevent damage to heart muscle following a heart attack and to reduce neurological damage following ischemic stroke —abbreviation tPA