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单词 thalidomide
释义

thalidomide

noun

tha·​lid·​o·​mide thə-ˈli-də-ˌmīd How to pronounce thalidomide (audio)
-məd
: a drug C13H10N2O4 that was formerly used as a sedative and is now used as an immunomodulatory agent especially in the treatment of leprosy and multiple myeloma and that is known to cause malformations of infants born to mothers using it during pregnancy

Example Sentences

Recent Examples on the Web First, though, with the promise of anonymity, Chessen called the local newspaper to warn the community about thalidomide. CBS News, 3 July 2022 The exclusion of women from clinical research was partly a safety measure as a result of the use of thalidomide to treat morning sickness in pregnant women in the 1950s, unknowingly causing thousands of birth defects. Laine Bruzek, Fortune, 10 June 2022 One was the morning sickness drug thalidomide, tested on American women in the 1950s, that could cause severe birth defects or stillbirths. New York Times, 9 June 2022 Within two years, reports surfaced that thalidomide caused horrific birth defects. Timothy Noah, The New Republic, 10 Feb. 2022 Although not a vaccine, in the 1950s a drug called thalidomide was prescribed for early-pregnancy nausea. Suzi Ring, BostonGlobe.com, 23 Dec. 2021 In the late 1950s, doctors began prescribing a new drug named thalidomide to pregnant women in Europe and North America, to ease their morning sickness. Samanth Subramanian, Quartz, 6 Oct. 2021 Among the key problems with thalidomide was the way it was manufactured. Samanth Subramanian, Quartz, 6 Oct. 2021 Although it was not approved by the Food and Drug Administration, thalidomide was given to Americans in trials. Brittany Shammas, Anchorage Daily News, 7 Oct. 2021 See More

Word History

Etymology

phthalic acid + -id- (from imide) + -o- + imide

First Known Use

1958, in the meaning defined above

Medical Definition

thalidomide

noun

tha·​lid·​o·​mide thə-ˈlid-ə-ˌmīd How to pronounce thalidomide (audio) -məd How to pronounce thalidomide (audio)
: a sedative, hypnotic, and antiemetic drug C13H10N2O4 that was formerly used chiefly in Europe during the late 1950s and early 1960s especially to treat morning sickness but was soon withdrawn after being shown to cause serious malformations (as missing or severely shortened arms and legs) in infants born to mothers using it during the first trimester of pregnancy and that is now used as an immunomodulatory agent chiefly in the treatment of cutaneous complications of leprosy and in combination with dexamethasone in the treatment of multiple myeloma
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更新时间:2025/1/9 7:01:22