: the complement of proteins expressed in a cell, tissue, or organism by a genome
Example Sentences
Recent Examples on the WebTheir algorithm gobbled up the entire human proteome and spat out a preliminary list of about 43,000 peptides. Max G. Levy, Wired, 30 Nov. 2021 Nautilus is developing a protein analysis platform with the goal to identify more than 95% of the proteome. John Cumbers, Forbes, 16 June 2021 Across the board, AlphaFold2 predicted 58% of amino acids in the human proteome — all the proteins expressed by the human body — with confidence, and 35.7% with a very high degree of confidence. Katie Palmer, STAT, 22 July 2021 Until recently, studying the proteome was extremely challenging. John Cumbers, Forbes, 16 June 2021 Their effort centers on building a proteome — the complete collection of proteins that LECA was probably capable of making.Quanta Magazine, 9 Apr. 2019 Moses’ lab, which receives support from the NIH, foundations, and philanthropic organizations, looks at how cancer affects an individual’s protein profile, or proteome, and compares the presence of these proteins in urine samples.BostonGlobe.com, 27 Sep. 2019 In 2012, Keith Dunker of Indiana University and his colleagues looked for these telltale stretches of amino acids in databases of eukaryotic and prokaryotic proteomes.Quanta Magazine, 24 Jan. 2017 Instead of identifying them one protein at a time, as has classically been done, Cravatt develops rules that apply to wide swathes of the universe of proteins, or the proteome. Bradley J. Fikes, sandiegouniontribune.com, 16 Oct. 2017 See More
Word History
Etymology
prote(in) + -ome (in genome)
Note: The term was first used in print in Valerie C. Wasinger, et al., "Progress with gene-product mapping of the Mollicutes: Mycoplasma genitalium," Electrophoresis, vol. 16, no. 7 (July, 1995), pp. 1090-94. According to Wikipedia (as of 6/30/21), proteome was coined by the Australian geneticist Marc R. Wilkins; see Marc R. Wilkins, et al., "Progress with Proteome Projects: Why All Proteins Expressed by a Genome Should be Identified and How To Do It," Biotechnology and Genetic Engineering Reviews, vol. 13 (1996), pp. 19-50; and Marc R. Wilkins, et al., "From Proteins to Proteomes: Large Scale Protein Identification by Two-Dimensional Electrophoresis and Amino Acid Analysis," Nature Biotechnology, vol. 14, issue 1 (January, 1996), pp. 61-65.
First Known Use
1995, in the meaning defined above
Medical Definition
proteome
noun
pro·te·ome ˈprōt-ē-ˌōm
: the complement of proteins expressed in a cell, tissue, or organism by a genome