Recent Examples on the WebBipolar affective disorder, formerly called manic-depressive illness, is a psychiatric condition that is frequently misdiagnosed. Dr. Keith Roach, oregonlive, 20 June 2022 One of those troubles is bipolar disorder, which used to be known simply as manic-depressive illness. Rick Kogan, chicagotribune.com, 22 Oct. 2019 Natural selection could have eliminated anxiety, depression, addiction, anorexia and the genes that cause autism, schizophrenia and manic-depressive illness. David P. Barash, WSJ, 13 Feb. 2019 Bipolar disorder, also called manic-depressive illness, is a disorder of the brain that causes extreme mood swings, including extreme emotional highs and lows. Ashley Welch, CBS News, 6 June 2018 He was diagnosed with bipolar disorder, a manic-depressive illness that afflicts more than 6 million American adults, according to the National Alliance on Mental Illness. Jessica Ravitz, CNN, 4 Oct. 2017