hyperkeratosis
noun
hy·per·ker·a·to·sis ˌhī-pər-ˌker-ə-ˈtō-səs 
plural hyperkeratoses ˌhī-pər-ˌker-ə-ˈtō-ˌsēz
: hypertrophy of the corneous layer of the skin
hyperkeratotic
ˌhī-pər-ˌker-ə-ˈtä-tik
adjective 
Example Sentences
Recent Examples on the Web Not only can weather changes and hyperkeratosis affect your pooch’s paws, but theseconditions can affect their noses as well. 
Nicole Forsyth, The Mercury News, 5 Sep. 2019 Or your dog may have a genetic condition called hyperkeratosis that makes their paws and noses vulnerable to becoming dry. Nicole Forsyth, The Mercury News, 5 Sep. 2019 Soften Up Don’t overlook the rest of your hands: Rough patches on the palms can be remedied using a callus softener like Deborah Lippmann’s Get Off, which uses lactic acid to break down hyperkeratosis (thickening of the skin). Donna Bulseco, WSJ, 2 May 2018
Nicole Forsyth, The Mercury News, 5 Sep. 2019 Or your dog may have a genetic condition called hyperkeratosis that makes their paws and noses vulnerable to becoming dry. Nicole Forsyth, The Mercury News, 5 Sep. 2019 Soften Up Don’t overlook the rest of your hands: Rough patches on the palms can be remedied using a callus softener like Deborah Lippmann’s Get Off, which uses lactic acid to break down hyperkeratosis (thickening of the skin). Donna Bulseco, WSJ, 2 May 2018 Word History
Etymology
earlier as a name for keratoconus (conical distortion of the cornea), borrowed from New Latin (in a German context), from hyper- hyper- + Greek kerat-, kéras "horn" + New Latin -osis -osis — more at kerato-
Note: As an ophthalmological term introduced by the German ophthalmologist Karl Himly (1772-1837) in Bibliothek für Ophthalmologie, 1. Band, 2. Stück (Hannover, 1819), p. 401.
First Known Use
1841, in the meaning defined above
Medical Definition
hyperkeratosis
noun
hy·per·ke·ra·to·sis -ˌker-ə-ˈtō-səs
plural hyperkeratoses -ˈtō-ˌsēz
1
: hypertrophy of the stratum corneum layer of the skin
2
a
: any of various conditions marked by hyperkeratosis
b
: a disease of cattle that is marked by thickening and wrinkling of the hide, by formation of papillary outgrowths on the buccal mucous membranes, and often by a watery discharge from eyes and nose, diarrhea, loss of weight, and abortion of pregnant animals and that is caused especially by ingestion of the chlorinated naphthalene of various lubricating oils, by arsenic poisoning, or by inherited congenital ichthyosis
called also X-disease, XX disease