: the signed minor of an element of a square matrix or of a determinant with the sign positive if the sum of the column number and row number of the element is even and with the sign negative if it is odd
2
: a substance that acts with another substance to bring about certain effects
especially: coenzyme
3
: something (such as diet or a virus) that acts with or aids another factor in causing disease
Example Sentences
Recent Examples on the WebChakravarty is among the COVID experts who think the coronavirus is worth a more serious look as a potential cause or cofactor. Erin Prater, Fortune, 19 May 2022 Cells in our body and skin need niacinamide to make cofactors necessary for keeping cells functioning properly and for carrying out various processes that occur in our body (like metabolism and damage repair). Danusia Wnek, Good Housekeeping, 28 Apr. 2020 Normally, the enzyme gets its electrons from an iron-containing cofactor. John Timmer, Ars Technica, 19 Dec. 2019 The vampire bat microbiome helps with the nutritional aspect of blood sucking by aiding with carbohydrate metabolism and synthesizing essential cofactors and vitamins lacking in blood. Diana Gitig, Ars Technica, 1 Mar. 2018
Word History
First Known Use
1885, in the meaning defined at sense 1
Medical Definition
cofactor
noun
co·fac·tor ˈkō-ˌfak-tər
1
: a substance that acts with another substance to bring about certain effects
especially: coenzyme
2
: something (as a diet or virus) that acts with or aids another factor in causing disease
Infection with the HPV virus is an important cofactor in cervical cancer, but very few people infected with HPV will ever get cervical cancer. Elissa Mendenhall, Mothering