Madonna
noun
Ma·don·na mə-ˈdä-nə 
1
archaic : lady —used as a form of respectful address
2
obsolete : an Italian lady
3
a
: virgin mary
b
: an artistic depiction (such as a painting or statue) of the Virgin Mary
4
: a morally pure and chaste woman
Word History
Etymology
Italian, from Old Italian ma donna, literally, my lady
First Known Use
1584, in the meaning defined at sense 1