单词	genetic mutation
释义	genetic mutation noun plural genetic mutations : a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy. Natalie Angier Word History First Known Use 1915, in the meaning defined above Medical Definition genetic mutation noun : a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells. Joseph Alper
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