: any of several intracellular proteases of animal tissue that aid in autolysis
Example Sentences
Recent Examples on the WebFortunately, Gerwick had encountered cathepsin inhibitors before. Stephanie Stone, Smithsonian Magazine, 2 Sep. 2021
Word History
Etymology
Greek kathepsein to digest (from kata- cata- + hepsein to boil) + English -in entry 2
First Known Use
1929, in the meaning defined above
Medical Definition
cathepsin
noun
ca·thep·sin kə-ˈthep-sən
: any of a class of proteases present in most animal tissues (as in kidney, liver, and spleen) that catalyze the hydrolysis of proteins to polypeptides
Cathepsins are lysosomal proteases that cleave their substrates with relatively low specificity. Arthur M. Krieg et al., Science
Recent investigations by several research groups, working with organisms as diverse as worms and monkeys, implicate cathepsins flooding the cytoplasm as a major cause of necrotic cell death. Nektarios Tavernarakis, New Scientist