单词	active site
释义	active site noun : a region on the surface of an enzyme whose shape permits binding only of a specific molecular substrate that then undergoes catalysis Example Sentences Recent Examples on the Web The fire was on private property owned by WR Grace, which isn’t an active site and went out of business, Arnum said. Matt Yan, BostonGlobe.com, 23 May 2022 Each enzyme has an active site, which is where the reaction takes place. Svenja Lohner, Scientific American, 10 Nov. 2016 Highlights of the still-active site include a 2011 warning to the entertainment industry about Apple TV and a decade-early defense of non-fungible tokens (NFTs). Alex Konrad, Forbes, 12 Apr. 2022 Many drugs are designed to fit into this active site, which can keep a protein from working. John Timmer, Ars Technica, 25 Mar. 2022 Errors affecting the enzyme’s active site that binds to drugs, however, can cripple its ability to break down a drug and subsequently mean there’s more of the drug circulating in the blood. C. Michael White, The Conversation, 4 Oct. 2021 There are multiple investigations still going on at the active site. Mariah Rush, chicagotribune.com, 2 July 2021 Subsequent studies report three drugs, boceprevir, narlaprevir, and telaprevir, inhibit NSP5 protease proteolytic activity and bind into its active site. William A. Haseltine, Forbes, 4 June 2021 While the active site of the NSP3 protease does not have much structural similarity with the HCV or NSP5 proteases, the researchers carried out virtual docking studies of these same 10 HCV drugs into the substrate-binding cleft of NSP3 protease. William A. Haseltine, Forbes, 4 June 2021 See More Word History First Known Use 1957, in the meaning defined above Medical Definition active site noun : a region especially of a biologically active protein (as an enzyme) where catalytic activity takes place and whose shape permits the binding only of a specific reactant molecule
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