单词	carbapenem
释义	carbapenem noun car·​ba·​pen·​em ˌkär-bə-ˈpe-nəm  : any of a class of broad-spectrum antibiotics (such as imipenem) resistant to hydrolysis by beta-lactamase Another class of antibiotics, carbapenems, is used as an antibiotic of last resort for the most persistent infections. Nicholas Bakalar Example Sentences Recent Examples on the Web Some of these tested positive for New Delhi metallo-beta-lactamase-1 (NDM-1), an enzyme that makes bacteria resistant to a class of important antibiotics known as carbapenems. David Mateo Ricci, STAT, 31 Dec. 2019 Between 12 percent and 71 percent — depending on the species tested — were also resistant to carbapenems, a class of antibiotics once considered the last line of defense. New York Times, 23 Dec. 2019 The urgent threats also included: Carbapenem-resistant acinetobacter; carbapenem-resistant enterobacteriaceae (CRE); drug-resistant Neisseria gonorrhoeae; and clostridioides difficile, or C. diff. Ryan W. Miller, USA TODAY, 16 Nov. 2019 Two groups of bacteria are also on the list: Acinetobacter, which is commonly found in soil and water and can cause infections in blood, the urinary tract, and the lungs, or in open wounds; and carbapenem-resistant Enterobacteriaceae, or CRE. Erika Edwards, NBC News, 13 Nov. 2019 Of those isolates, about 25 percent produced carbapenem-thwarting enzymes called carbapenemases. Beth Mole, Ars Technica, 4 Apr. 2018 The rise of antibiotic-resistant superbugs such as CRE (carbapenem-resistant Enterobacteriaceae), which can be fatal in up to half of patients, has made addressing these problems more urgent. Chad Terhune, latimes.com, 23 Apr. 2018 The rise of antibiotic-resistant superbugs such as CRE (carbapenem-resistant Enterobacteriaceae), which can be fatal in up to half of patients, has made addressing these problems more urgent. Chad Terhune, Washington Post, 23 Apr. 2018 Last year, public health labs around the country were asked to watch for and quickly respond to cases of advanced antibiotic resistance, especially to some last-resort antibiotics called carbapenems. Washington Post, 3 Apr. 2018 See More Word History First Known Use 1979, in the meaning defined above Medical Definition carbapenem noun car·​ba·​pen·​em ˌkär-bə-ˈpe-nəm  : any of a class of broad-spectrum beta-lactam antibiotics (such as imipenem) having a five-membered ring system similar to the penicillins but containing a carbon atom instead of a sulfur atom It rendered the Klebsiella, which was already resistant to many antibiotics used in critical care medicine, insensitive to the only remaining group that worked reliably and safely—the carbapenems, the so-called drugs of last resort. Maryn McKenna, Scientific American
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