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单词 epitope
释义

epitope

noun

epi·​tope ˈe-pə-ˌtōp How to pronounce epitope (audio)
: a molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response

called also determinant, antigenic determinant

Example Sentences

Recent Examples on the Web The most prevalent mutation in this T cell epitope is an amino acid substitution of proline for leucine, denoted as YLQLRTFLL or P272L mutation. William A. Haseltine, Forbes, 17 Aug. 2022 One potential benefit might be longer-lasting protection, Greenberger speculated, since the coronavirus is unlikely to mutate every protein epitope included in this vaccine. Angus Chen, STAT, 14 Apr. 2022 This mAb, derived from B cells of a patient who recovered from SARS-1 in 2003, targets an epitope on the S protein that is conserved in the sarbecovirus family. Laura Defrancesco, Scientific American, 6 Jan. 2022 The portion of the pathogen's protein that the antibody recognizes is called an epitope. John Timmer, Ars Technica, 13 Jan. 2022 Sequence conservation at the BG10-19 epitope explains the cross-neutralization against SARS-1, as 23 of 29 residues are conserved between SARS-1 and SARS-CoV-2 RBDs. William A. Haseltine, Forbes, 11 May 2021 On the top of the protein, a spot called an epitope serves as a landing pad for antibodies, allowing the virus to be neutralized. Lawrence Wright, The New Yorker, 28 Dec. 2020 Unlike monoclonal antibodies, which are being developed to target a specific molecular region, or epitope, on the surface of SARS-CoV-2 to elicit an immune response, horse polyclonal antibodies against SARS-CoV-2 recognize multiple epitopes. Debbie Ponchner, Scientific American, 17 Aug. 2020 The observation of this study raised the alarm that Sars-CoV-2 mutation that varied epitope (something that an antibody attaches itself to) profile could arise at any time. Barnini Chakraborty, Fox News, 15 Apr. 2020 See More

Word History

Etymology

epi- + Greek tópos "place"

Note: Term introduced by the Danish immunologist Niels Kaj Jerne (1911-94) in "Immunological speculations," Annual Review of Microbiology, vol. 14 (1960), pp. 341-58.

First Known Use

1960, in the meaning defined above

Medical Definition

epitope

noun

epi·​tope ˈep-ə-ˌtōp How to pronounce epitope (audio)
: a molecular region on the surface of an antigen capable of eliciting an immune response and of combining with the specific antibody produced by such a response

called also determinant, antigenic determinant

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更新时间:2025/1/31 1:27:15