monoclonal
1 of 2adjective
mono·clo·nal ˌmä-nə-ˈklō-nᵊl 
: produced by, being, composed of, or caused by cells derived from a single cell
… Dr. [Lawrence] Kaplan said tumors that were monoclonal, arising from a single malignant cell, indicated poor survival.
Marilyn Chase
Marilyn Chase especially : relating to, being, or caused by a monoclonal antibody or monoclonal antibodies
monoclonal assays
see also monoclonal gammopathy monoclonal
2 of 2noun
plural monoclonals
: monoclonal antibody
But now researchers say that new ways of modifying antibodies promise to deliver monoclonals in more effective forms, with fewer side effects and at lower cost. Lawrence M. Fisher
Lawrence M. Fisher
Example Sentences
Recent Examples on the Web Brenda Goodman, CNN, 1 Sep. 2022 The medication, administered in a series of two injections, provides recipients with monoclonal antibodies. Karen Kaplan, Los Angeles Times, 11 Aug. 2022 Researchers have been studying the use of various monoclonal antibodies and antivirals such as Remdesivir and Favipiravir. Bruce Y. Lee, Forbes, 4 Aug. 2022 He was quickly started on an aggressive course of treatments, including an intravenous infusion of the antiviral medication remdesivir and a cocktail of monoclonal antibodies. Monique Brouillette, Scientific American, 22 July 2022 Doctors typically treat hospital patients with steroids, remdesivir, and monoclonal antibodies. Globe Staff, BostonGlobe.com, 22 July 2022 In some cases, doctors may choose to administer alternative treatments, such as an infusion of monoclonal antibodies, according to the U.S Department of Health and Human Services. Sarah Ladd, The Courier-Journal, 21 July 2022 Today, Griffin said, the antiviral Paxlovid is considered more effective than monoclonal antibodies, most of which don't work well against omicron and its subvariants. Karen Weintraub, USA TODAY, 21 July 2022 This is part of a broader switch away from monoclonal antibodies, which Zink said are typically more expensive, harder to distribute, less effective and less convenient than the oral antivirals Paxlovid and molnupiravir. Annie Berman, Anchorage Daily News, 13 July 2022 See More
Adjective
Some of the monoclonal antibodies made to give people passive immunity against the virus have also stopped working against the new variants. Brenda Goodman, CNN, 1 Sep. 2022 The medication, administered in a series of two injections, provides recipients with monoclonal antibodies. Karen Kaplan, Los Angeles Times, 11 Aug. 2022 Researchers have been studying the use of various monoclonal antibodies and antivirals such as Remdesivir and Favipiravir. Bruce Y. Lee, Forbes, 4 Aug. 2022 He was quickly started on an aggressive course of treatments, including an intravenous infusion of the antiviral medication remdesivir and a cocktail of monoclonal antibodies. Monique Brouillette, Scientific American, 22 July 2022 Doctors typically treat hospital patients with steroids, remdesivir, and monoclonal antibodies. Globe Staff, BostonGlobe.com, 22 July 2022 In some cases, doctors may choose to administer alternative treatments, such as an infusion of monoclonal antibodies, according to the U.S Department of Health and Human Services. Sarah Ladd, The Courier-Journal, 21 July 2022 Today, Griffin said, the antiviral Paxlovid is considered more effective than monoclonal antibodies, most of which don't work well against omicron and its subvariants. Karen Weintraub, USA TODAY, 21 July 2022 This is part of a broader switch away from monoclonal antibodies, which Zink said are typically more expensive, harder to distribute, less effective and less convenient than the oral antivirals Paxlovid and molnupiravir. Annie Berman, Anchorage Daily News, 13 July 2022 See More Word History
First Known Use
Adjective
1914, in the meaning defined above
Noun
1980, in the meaning defined above
Phrases Containing monoclonal
Medical Definition
monoclonal 1 of 2
adjective
mono·clo·nal ˌmän-ə-ˈklōn-ᵊl
: produced by, being, or composed of cells derived from a single cell
a monoclonal tumor
especially : relating to or being an antibody derived from a single cell in large quantities for use against a specific antigen (as a cancer cell)
monoclonal
2 of 2noun
: a monoclonal antibody