Esters of crotonic acid were brominated on a multigramme scale using a free radical procedure.
James A. B. Laurenson, John A. Parkinson, Jonathan M. Percy, Giuseppe Rinaudo, RicardRoig 2013, 'Multigramme synthesis and asymmetric dihydroxylation of a 4-fluorobut-2E-enoate',Beilstein Journal of Organic Chemistryhttps://doi.org/10.3762/bjoc.9.301. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, crotonylation induced by crotonic acid facilitates telomere maintenance and enhances chemically induced reprogramming to pluripotency.
Haifeng Fu, Cheng-lei Tian, Xiaoying Ye, Xiaoyan Sheng, Hua Wang, Yifei Liu, Lin Liu 2018, 'Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells',Stem Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2213671118302200. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)