a medical treatment using a single drug or therapy
Examples of 'monotherapies' in a sentence
monotherapies
As monotherapies for solid tumors, oncolytic virotherapy provides only moderate anti-tumor effects.
Amanda Rosewell Shaw, Amanda Rosewell Shaw, Masataka Suzuki, Masataka Suzuki 2018, 'Oncolytic Viruses Partner With T-Cell Therapy for Solid Tumor Treatment', Frontiers in Immunologyhttps://www.frontiersin.org/article/10.3389/fimmu.2018.02103/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Combination partly increased the therapeutic effects in comparison to the respective monotherapies.
Birgit Hotz, Marina V. Backer, Joseph M. Backer, Heinz-J. Buhr, Hubert G. Hotz 2010, 'Specific Targeting of Tumor Endothelial Cells by a Shiga-like Toxin-Vascular EndothelialGrowth Factor Fusion Protein as a Novel Treatment Strategy for Pancreatic Cancer',Neoplasia: An International Journal for Oncology Researchhttp://www.sciencedirect.com/science/article/pii/S1476558610800478. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most patients were treated with conventional antihypertensive monotherapies (n = 838, 63.5%).
Witt Claudia M, Bockelbrink Angelina, Kröz Matthias, Vollmar Horst C, Ostermann Thomas,Jeschke Elke, Willich Stefan N, Matthes Harald 2009, 'Evaluation of prescribing patterns in a German network of CAM physicians for the treatmentof patients with hypertension: a prospective observational study', BMC Family Practicehttp://www.biomedcentral.com/1471-2296/10/78. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Indications are that antimalarial monotherapies are being "crowded out" of the market.
Gabra Michael, Embrey Martha, Mlaki Wilson, Mbwasi Romuald, Liana Jafary, McKinnonBrittany, Kibassa Bryceson, Rutta Edmund, Shekalaghe Elizabeth, Kimatta Suleiman,Sillo Hiiti 2011, 'Increasing Access to Subsidized Artemisinin-based Combination Therapy through AccreditedDrug Dispensing Outlets in Tanzania', Health Research Policy and Systemshttp://www.health-policy-systems.com/content/9/1/22. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, the combined treatment showed better results compared to rosuvastatin or omeprazole monotherapies.
Ebtsam M. Fouad, Samah M. Elaidy, Soha S. Essawy 2017, 'Anti-ulcerative, Anti-oxidative, and Anti-inflammatory Effects of Rosuvastatin andIsosorbide Dinitrate on Cysteamine-Induced Chronic Duodenal Ulcer in Rats', Egyptian Journal of Basic and Clinical Pharmacologyhttp://www.kenzpub.com/journals/ejbcp/2017/101361/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Approximately fifty percent of the prescriptions were monotherapies.
Abegaz TM, Tefera YG, Abebe TB 2017, 'Antihypertensive drug prescription patterns and their impact on outcome of blood pressurein Ethiopia: a hospital-based cross-sectional study', Integrated Pharmacy Research and Practicehttps://www.dovepress.com/antihypertensive-drug-prescription-patterns-and-their-impact-on-outcom-peer-reviewed-article-IPRP. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The superiority of combination therapies over monotherapies requires further support.
Rüdiger Hardeland 2011, 'Cognitive Enhancers in Moderate to Severe Alzheimer's Disease', Clinical Medicine Insights: Therapeuticshttps://doi.org/10.4137/CMT.S6344. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The majority have not fared well as monotherapies for improving survival of these patients.
Harsh B. Pathak, Yan Zhou, Geetika Sethi, Jeff Hirst, Russell J. Schilder, Erica A.Golemis, Andrew K. Godwin 2015, 'A Synthetic Lethality Screen Using a Focused siRNA Library to Identify Sensitizersto Dasatinib Therapy for the Treatment of Epithelial Ovarian Cancer', PLOS ONE10.1371/journal.pone.0144126. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Combination therapy was superior to monotherapies in reducing hepatic steatosis, inflammation, and fibrosis.
Hani Jouihan, Sarah Will, Silvia Guionaud, Michelle L. Boland, Stephanie Oldham, PeterRavn, Anthony Celeste, James L. Trevaskis 2017, 'Superior reductions in hepatic steatosis and fibrosis with co-administration of aglucagon-like peptide-1 receptor agonist and obeticholic acid in mice', Molecular Metabolismhttp://www.sciencedirect.com/science/article/pii/S2212877817303010. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antimalarial agents should be used with caution; monotherapies should be avoided.
Fatima Shujatullah, Haris M. Khan, Abida Khatoon, Parvez A. Khan, Mohammad Ashfaq 2012, 'In Vitro Chloroquine Resistance in Plasmodium falciparum Isolates from Tertiary CareHospital', Malaria Research and Treatmenthttp://dx.doi.org/10.1155/2012/538481. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)