a chemical composition that only has one phosphate group
adenosine monophosphate
monophosphate in American English
(ˌmɑnəˈfɑsfeit)
noun
Chemistry
a salt containing only one phosphate group
Word origin
[mono- + phosphate]mono- is a combining form meaning “alone,” “single,” “one” (monogamy); specialized in some scientific terms to denote a monomolecular thickness (monolayer) and adapted in chemistry to apply to compounds containing one atom of a particularelement (monohydrate). Other words that use the affix mono- include: monoacid, monochromatic, monocoque, monopoly, monorail
Examples of 'monophosphate' in a sentence
monophosphate
The concentration of cavernous cyclic guanosine monophosphate was detected by enzyme-linked immunosorbent assay.
Zhang-Yan Zhou, Guang-Jun Zhong, Shao-Ping Cheng, Hui Huang, Jing Wang, Hui Pan, Chang-MaoLiu, Cheng Xing, Ya-Ling Sun, Rong-Hua Liu, Fei-Li 2016, 'Short hairpin RNA targeting insulin-like growth factor binding protein-3 restoresthe bioavailability of insulin-like growth factor-1 in diabetic rats', International Brazilian Journal of Urologyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382016000100139&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Finally, the induction of cell lysis in the ura4 deletion mutant was due to the accumulation of orotidine-5-monophosphate.
Yuzy Matsuo, Kouhei Nishino, Kouhei Mizuno, Takashi Akihiro, Takashi Toda, YasuhiroMatsuo, Tomohiro Kaino, Makoto Kawamukai 2013, 'Polypeptone Induces Dramatic Cell Lysis in ura4 Deletion Mutants of Fission Yeast',PLoS ONE10.1371/journal.pone.0059887. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Metabolic activation of nucleobases involves condensation with 5-phosphoribosyl-1-pyrophosphate to give the corresponding nucleoside-5'-monophosphate.
Li Qiu, Steven E Patterson, Laurent F Bonnac, Robert J Geraghty 2018, 'Nucleobases and corresponding nucleosides display potent antiviral activities againstdengue virus possibly through viral lethal mutagenesis.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC5929572?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The enzyme hydrolyzes nucleotides tri- and/or di-phosphate into monophosphate products, which are subsequently hydrolyzedinto adenosine.
Nalu Teixeira de Aguiar Peres, Nalu Teixeira de Aguiar Peres, Luana Celina SeraphimCunha, Meirielly Lima Almeida Barbosa, Márcio Bezerra Santos, Márcio Bezerra Santos,Fabrícia Alvise de Oliveira, Amélia Maria Ribeiro de Jesus, Amélia Maria Ribeiro deJesus, Roque Pacheco de Almeida, Roque Pacheco de Almeida 2018, 'Infection of Human Macrophages by Leishmania infantum Is Influenced by Ecto-Nucleotidases',Frontiers in Immunologyhttp://journal.frontiersin.org/article/10.3389/fimmu.2017.01954/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Significantly, when 5′-ribose monophosphate was used, multiple additions to the aforementioned primer were observed that resulted in hybrid polymers.
Niraja V. Bapat, Sudha Rajamani 2018, 'Templated replication (or lack thereof) under prebiotically pertinent conditions',Scientific Reportshttp://link.springer.com/article/10.1038/s41598-018-33157-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thymidine kinase converts 5-fluorodeoxyuridine to 5-fluorodeoxyuridine monophosphate, which causesdisruption of deoxynucleotide triphosphate ratios.
Hossain Mohammad Shamim, Yukako Minami, Daiki Tanaka, Shinobu Ukimori, Johanne M.Murray, Masaru Ueno 2017, 'Fission yeast strains with circular chromosomes require the 9-1-1 checkpoint complexfor the viability in response to the anti-cancer drug 5-fluorodeoxyuridine', PLOS ONE10.1371/journal.pone.0187775. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The de novo biosynthesis of purine depends on six enzymes to catalyze the conversion of phosphoribosylpyrophosphate to inosine 5′-monophosphate.
Jie Yin, Jie Yin, Jie Yin, Wenkai Ren, Xingguo Huang, Xingguo Huang, Jinping Deng,Tiejun Li, Yulong Yin, Yulong Yin 2018, 'Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy', Frontiers in Immunologyhttps://www.frontiersin.org/article/10.3389/fimmu.2018.01697/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Activation of gluconeogenesis along with hexose monophosphate shunt and urea cycle probably helped the animals to combat the heat stress.
Kataria N., Kataria A.K. 2012, 'Heat stress induced changes in metabolic regulators of donkeys from arid tracts inIndia', Journal of Stress Physiology & Biochemistryhttp://www.jspb.ru/issues/2012/N2/JSPB_2012_2_193-198.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)