an interaction between structural units within a molecule or between molecules in an assemblage that enables the system to respond more sharply to an external change than would isolated units
cooperativity in American English
(kouˌɑpərəˈtɪvɪti)
noun
Biochemistry
the increase or decrease in the rate of interaction between a reactant and a protein as the reactant concentration increases
Also: co-operativity
Word origin
[cooperative + -ity]-ity is a suffix used to form abstract nouns expressing state or condition. Other wordsthat use the affix -ity include: Latinity, civility, jollity
Examples of 'cooperativity' in a sentence
cooperativity
The modularity of cellular function and cooperativity between modules are also discussed.
Wang Xia, Yue Junjie, Ren Xianwen, Wang Yuelan, Tan Mingfeng, Li Beiping, Liang Long 2011, 'Modularity analysis based on predicted protein-protein interactions provides new insightsinto pathogenicity and cellular process of Escherichia coli O157:H7', Theoretical Biology and Medical Modellinghttp://www.tbiomed.com/content/8/1/47. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cooperativity can be positive (supralinear) or negative (infralinear).
Melanie I Stefan, Nicolas Le Novère 2013, 'Cooperative binding.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC3699289?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Five others had a pattern of expression that suggested cooperativity between the co-expressed oncoproteins.
Arnouk Hilal, Podolsky Robert H, Hildebrandt Ellen, Merkley Mark A, Ferris Daron G,Dynan William S, Stöppler Hubert 2009, 'Large-scale analysis of protein expression changes in human keratinocytes immortalizedby human papilloma virus type 16 E6 and E7 oncogenes', Proteome Sciencehttp://www.proteomesci.com/content/7/1/29. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
They show that modular structures fold and interact with limited, incremental cooperativity.
Brant Gracia, Hashim M. Al-Hashimi, Namita Bisaria, Rhiju Das, Daniel Herschlag, RickRussell 2018, 'Hidden Structural Modules in a Cooperative RNA Folding Transition', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124718303115. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We show the spontaneous cooperativity in a complex physical system with decentralized control.
Georg Martius, Ralf Der, Nihat Ay 2013, 'Information driven self-organization of complex robotic behaviors.', PLoS ONEhttp://europepmc.org/articles/PMC3664628?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Double-reciprocal plots showed no cooperativity for this enzyme.
Nicolás Forero-Baena, Diana Sánchez-Lancheros, July Constanza Buitrago, Victor Bustos,María Helena Ramírez-Hernández 2015, 'Identification of a nicotinamide/nicotinate mononucleotide adenylyltransferase inGiardia lamblia (GlNMNAT)', Biochimie Openhttp://www.sciencedirect.com/science/article/pii/S2214008515000085. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The convergence of these carbon-based materials and bioelectronics ensures scalability and cooperativity in various fields.
Taemin Kim, Myeongki Cho, Ki Jun Yu 2018, 'Flexible and Stretchable Bio-Integrated Electronics Based on Carbon Nanotube and Graphene',Materialshttp://www.mdpi.com/1996-1944/11/7/1163. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Folding cooperativity, the all or nothing folding of a protein, can reduce this aggregation propensity.
V V Hemanth Giri Rao, Shachi Gosavi 2014, 'In the multi-domain protein adenylate kinase, domain insertion facilitates cooperativefolding while accommodating function at domain interfaces.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC4230728?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Only the trimer exhibited positive cooperativity at high temperatures.
Olga Kolaj-Robin, Mohamed R Noor, Sarah R O'Kane, Frauke Baymann, Tewfik Soulimane 2013, 'Atypical features of Thermus thermophilus succinate:quinone reductase.', PLoS ONEhttp://europepmc.org/articles/PMC3538594?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we investigated the molecular mechanisms of this cooperativity, by using molecular dynamics simulations.
Kota Kasahara, Masaaki Shiina, Ikuo Fukuda, Kazuhiro Ogata, Haruki Nakamura 2017, 'Molecular mechanisms of cooperative binding of transcription factors Runx1-CBFβ-Ets1on the TCRα gene enhancer.', PLoS ONEhttp://europepmc.org/articles/PMC5322934?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)