any corticosteroid that controls electrolyte and water balance, esp by promoting retention of sodium by the kidney tubules
mineralocorticoid in American English
(ˌmɪnərəlouˈkɔrtɪˌkɔid)
noun
1. Biochemistry
any of a group of corticosteroid hormones, synthesized by the adrenal cortex, that regulate the excretion or reabsorption of sodium and potassium by the kidneys, salivary glands, and sweat glands
2. Pharmacology
any of various natural or synthetic drugs having mineralocorticoid activity
Word origin
[1945–50; mineral + -o- + cortic(o)- + -oid]This word is first recorded in the period 1945–50. Other words that entered Englishat around the same time include: beeper, fail-safe, on-line, poison pill, taxi squad-o- is the typical ending of the first element of compounds of Greek origin (as -i- is, in compounds of Latin origin), used regularly in forming new compounds with elementsof Greek origin and often used in English as a connective irrespective of etymology(Franco-Italian; geography; seriocomic; speedometer); -oid is a suffix meaning “resembling,” “like,” used in the formation of adjectives andnouns (and often implying an incomplete or imperfect resemblance to what is indicatedby the preceding element). Other words that use the affix -oid include: cardioid, cuboid, lithoid, ovoid, planetoid
Examples of 'mineralocorticoid' in a sentence
mineralocorticoid
This effect was blocked by glucocorticoid receptor antagonism but not by mineralocorticoid antagonism.
Ruth Morgan, John Keen, Daniel Halligan, Alan O'Callaghan, Ruth Andrew, Dawn Livingstone,Amber Abernethie, Giorgia Maltese, Brian Walker, Patrick Hadoke 2018, 'Species-specific regulation of angiogenesis by glucocorticoids reveals contrastingeffects on inflammatory and angiogenic pathways', PLOS ONE10.1371/journal.pone.0192746. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Mineralocorticoid receptors and aldosterone appear to play a role in memory.
Lukas Engler, Christian Adolf, Daniel A Heinrich, Anna-Katharine Brem, Anna Riester,Anna Franke, Felix Beuschlein, Martin Reincke, Axel Steiger, Heike Künzel 2019, 'Effects of chronically high levels of aldosterone on different cognitive dimensions:an investigation in patients with primary aldosteronism', Endocrine Connectionshttps://ec.bioscientifica.com/view/journals/ec/8/4/EC-19-0043.xml. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our study proposes a safety regiment for mineralocorticoid replacement during this critical developmental period.
Larissa G. Gomes, Guiomar Madureira, Berenice B. Mendonca, Tania A. S. S. Bachega 2013, 'Mineralocorticoid replacement during infancy for salt wasting congenital adrenal hyperplasiadue to 21-hydroxylase deficiency', Clinicshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000200005. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This situation may increase the risk of abiraterone-induced mineralocorticoid excess.
Yutaka Yamamoto, Yasunori Akashi, Takahumi Minami, Masahiro Nozawa, Keisuke Kiba,Motokiyo Yoshikawa, Akihide Hirayama, Hirotsugu Uemura 2018, 'Serious Hypokalemia Associated with Abiraterone Acetate in Patients with Castration-ResistantProstate Cancer', Case Reports in Urologyhttp://dx.doi.org/10.1155/2018/1414395. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Importantly we also observed mineralocorticoid receptors at postsynaptic membrane densities of excitatory synapses.
Eric M Prager, Jennifer Brielmaier, Hadley C Bergstrom, Jennifer McGuire, Luke R Johnson 2010, 'Localization of mineralocorticoid receptors at mammalian synapses.', PLoS ONEhttp://europepmc.org/articles/PMC3002274?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These laboratory abnormalities may be due to an apparent mineralocorticoid excess syndrome.
Aurelio Negro, Rosaria Santi, Chiara Grasselli, Simona Davoli, Franco Perazzoli 2013, 'A case of posterior reversible encephalopathy syndrome in the setting of post-partumpreeclampsia with suppressed plasma aldosterone levels and plasma renin activity',Italian Journal of Medicinehttp://www.italjmed.org/index.php/ijm/article/view/80. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In murine models of myocardial infarction, mineralocorticoid receptor antagonists reduce infarct size.
T N A van den Berg, Jaap Deinum, Albert Bilos, A Rogier T Donders, Gerard A Rongen,Niels P Riksen 2014, 'The effect of eplerenone on adenosine formation in humans in vivo: a double-blindedrandomised controlled study.', PLoS ONEhttp://europepmc.org/articles/PMC4214740?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Immunoblot analysis revealed the presence of mineralocorticoid receptors in the amygdala.
Eric M Prager, Jennifer Brielmaier, Hadley C Bergstrom, Jennifer McGuire, Luke R Johnson 2010, 'Localization of mineralocorticoid receptors at mammalian synapses.', PLoS ONEhttp://europepmc.org/articles/PMC3002274?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The mineralocorticoid receptor inhibitor spironolactone abolished aldosterone-induced accumulation of these aggregates.
Muhammad Umar Cheema, Helle Hasager Damkier, Jakob Nielsen, Ebbe Toftgaard Poulsen,Jan J Enghild, Robert A Fenton, Jeppe Praetorius 2014, 'Distal renal tubules are deficient in aggresome formation and autophagy upon aldosteroneadministration.', PLoS ONEhttp://europepmc.org/articles/PMC4085037?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)