designating an amount of substance of the order of micromoles
Examples of 'micromolar' in a sentence
micromolar
Apparent affinities are in the micromolar range based on surface plasmon resonance studies.
Milla Summanen, Niko Granqvist, Raimo K. Tuominen, Marjo Yliperttula, C. Theo Verrips,Johannes Boonstra, Christophe Blanchetot, Elina Ekokoski 2012, 'Kinetics of PKCε Activating and Inhibiting Llama Single Chain Antibodies and TheirEffect on PKCε Translocation in HeLa Cells', PLoS ONE10.1371/journal.pone.0035630. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The calculated equilibrium dissociation constants were in the lower micromolar range.
Marina Klemenčič, Marko Novinec, Silke Maier, Ursula Hartmann, Brigita Lenarčič 2013, 'The Heparin-Binding Activity of Secreted Modular Calcium-Binding Protein 1 (SMOC-1)Modulates Its Cell Adhesion Properties', PLoS ONE10.1371/journal.pone.0056839. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The peptides were linear with low micromolar binding affinities.
Peter Durand Skottrup, Grete Sørensen, Miroslaw Ksiazek, Jan Potempa, Erik Riise 2012, 'A Phage Display Selected 7-mer Peptide Inhibitor of the Tannerella forsythia Metalloprotease-LikeEnzyme Karilysin can be Truncated to Ser-Trp-Phe-Pro', PLoS ONE10.1371/journal.pone.0048537. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This protein binds several flavonoids with micromolar dissociation constants.
Jiao Zhu, Mengbuo Guo, Liping Ban, Li-Mei Song, Yang Liu, Paolo Pelosi, Guirong Wang 2018, 'Niemann-Pick C2 Proteins: A New Function for an Old Family', Frontiers in Physiologyhttp://journal.frontiersin.org/article/10.3389/fphys.2018.00052/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Based on liquid growth inhibition assays, it has potent antifungal activity in the micromolar range.
Gabriela eAyroza, Gabriela eAyroza, Ivan Lavander Candido Ferreira, Raphael SantaRosa Sayegh, Alexandre K. Tashima, Alexandre K. Tashima, Pedro Ismael eDa Silva Junior 2012, '"Juruin: an antifungal peptide from the venom of the Amazonian Pink Toe spider,Avicularia juruensis, which contains the inhibitory cystine knot motif"', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00324/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The remaining ophiobolins were mainly inactive or only slightly active at micromolar concentrations.
Tanja Thorskov Bladt, Claudia Dürr, Peter Boldsen Knudsen, Sara Kildgaard, Jens ChristianFrisvad, Charlotte Held Gotfredsen, Martina Seiffert, Thomas Ostenfeld Larsen 2013, 'Bio-Activity and Dereplication-Based Discovery of Ophiobolins and Other Fungal SecondaryMetabolites Targeting Leukemia Cells', Moleculeshttp://www.mdpi.com/1420-3049/18/12/14629. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Borneol at micromolar concentrations did not affect the viability of human cornealepithelial cells.
Gui-Lan Chen, Ming Lei, Lu-Ping Zhou, Bo Zeng, Fangdong Zou 2016, 'Borneol Is a TRPM8 Agonist that Increases Ocular Surface Wetness.', PLoS ONEhttp://europepmc.org/articles/PMC4957794?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Two molecules showed significant inhibitory activity (low micromolar/nanomolar range) against both proteins.
Chiara Ruggeri, Nyssa Drinkwater, Komagal Kannan Sivaraman, Rebecca S Bamert, SheenaMcGowan, Alessandro Paiardini 2015, 'Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 andM17 Aminopeptidases Using Virtual Screening.', PLoS ONEhttp://europepmc.org/articles/PMC4583420?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Several inhibitors showed micromolar or better efficacy against these organisms in culture.
Rosario Diaz-Gonzalez, F Matthew Kuhlmann, Cristina Galan-Rodriguez, Luciana Madeirada Silva, Manuel Saldivia, Caitlin E Karver, Ana Rodriguez, Stephen M Beverley, MiguelNavarro, Michael P Pollastri 2011, 'The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affordsa new opportunity for drug repurposing.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC3160303?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)