[1875–80; ‹ Gk métōp(on) forehead + -ic]This word is first recorded in the period 1875–80. Other words that entered Englishat around the same time include: authoritarian, cross-fertilization, knockabout, massage, neoclassic-ic is a suffix forming adjectives from other parts of speech, occurring originally inGreek and Latin loanwords (metallic; poetic; archaic; public) and, on this model, used as an adjective-forming suffix with the particular senses“having some characteristics of” (opposed to the simple attributive use of the basenoun) (balletic; sophomoric); “in the style of” (Byronic; Miltonic); “pertaining to a family of peoples or languages” (Finnic; Semitic; Turkic)
Vicente José Assencio-Ferreira, Ronaldo Abraham, José Carlos Esteves Veiga, KéciaCristina dos Santos 2001, 'Cranioestenose da sutura metópica: efeito teratogênico do valproato de sódio. Relatode caso Metopic suture craniosynostosis: sodium valproate teratogenic effect. Casereport', Arquivos de Neuro-Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000300020. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Divergent expression was dependent on synostosis sub-type, and was extensive in metopic craniosynostosis specifically.
Brendan D. Stamper, Sarah S. Park, Richard P. Beyer, Theo K. Bammler, Michael L. Cunningham 2012, 'Unique Sex-Based Approach Identifies Transcriptomic Biomarkers Associated with Non-SyndromicCraniosynostosis', Gene Regulation and Systems Biologyhttps://doi.org/10.4137/GRSB.S9693. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In the neonatal period, the infant had craniofacial dimorphism with metopic suture prominence.
A. Pinto, M.F. Almeida, A. Cunha, C. Carmona, S. Rocha, A. Guimas, R. Ribeiro, C.R.Mota, E. Martins, A. MacDonald, J.C. Rocha 2017, 'Dietary management of maternal phenylketonuria with glycomacropeptide and amino acidssupplements: A case report', Molecular Genetics and Metabolism Reportshttp://www.sciencedirect.com/science/article/pii/S2214426917301222. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Delayed closure of the anterior fontanelle and of metopic sutures causes frontal bossing.
S Manoj Kumar, Chandra Mouli, P Mahesh Kumar, S Kailasam 2012, 'Cleidocranial dysplasia in son and father: Report of two rare cases with review ofliterature', Journal of Indian Academy of Oral Medicine and Radiologyhttp://www.jiaomr.in/article.asp?issn=0972-1363;year=2012;volume=24;issue=2;spage=158;epage=161;aulast=Kumar. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Failure of this closure beyond 8 years leads to persistent metopic suture.
S Vikram, Jagadish Rao Padubidri, Aswini R. Dutt 2014, 'A rare case of persistent metopic suture in an elderly individual: Incidental autopsyfinding with clinical implications', Archives of Medicine and Health Scienceshttp://www.amhsjournal.org/article.asp?issn=2321-4848;year=2014;volume=2;issue=1;spage=61;epage=63;aulast=Vikram. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Metopic suture may mimic skull fracture and may mislead an inexperienced forensic expert.
S Vikram, Jagadish Rao Padubidri, Aswini R. Dutt 2014, 'A rare case of persistent metopic suture in an elderly individual: Incidental autopsyfinding with clinical implications', Archives of Medicine and Health Scienceshttp://www.amhsjournal.org/article.asp?issn=2321-4848;year=2014;volume=2;issue=1;spage=61;epage=63;aulast=Vikram. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
To assess the corpus callosum, a transfrontal plane was obtained using the metopic suture as an acoustic window.
Milena Visentainer, Edward Araujo Júnior, Liliam Cristine Rolo, Luciano MarcondesMachado Nardozza, Antonio Fernandes Moron 2010, 'Avaliação do comprimento e área do corpo caloso fetal por meio da ultrassonografiatridimensional Assessment of length and area of corpus callosum by three-dimensionalultrasonography', Revista Brasileira de Ginecologia e Obstetríciahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032010001200002. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Patients (90%) with isolated metopic craniosynostosis underwent cranial vault expansion, whereas only 63% of the complex group did so.
Craig B. Birgfeld, MD, Carrie L. Heike, MD, Babette S. Saltzman, PhD, Anne V. Hing,MD 2013, 'Clinical Characteristics and Surgical Decision Making for Infants with Metopic Craniosynostosisin Conjunction with Other Congenital Anomalies', Plastic and Reconstructive Surgery, Global Openhttp://journals.lww.com/prsgo/Fulltext/2013/10000/Article.5.aspx. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, distinct expression profiles for each unfused suture type were noted, with the metopic suture being most disparate.
Morris C Phillip, Hughes Ian P, Wilkinson Christopher R, Coussens Anna K, van DaalAngela, Anderson Peter J, Powell Barry C 2007, 'Unravelling the molecular control of calvarial suture fusion in children with craniosynostosis',BMC Genomicshttp://www.biomedcentral.com/1471-2164/8/458. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)