a drug used to treat hypertension. Formula: C10H13NO4
Word origin
C20: from methyl + d(ihydr)o(xy)p(henyl)a(lanine)
methyldopa in American English
(ˌmeθəlˈdoupə)
noun
Pharmacology
a white powder, C10H13NO4, used in the treatment of hypertension
Word origin
[1950–55; methyl- + dopa]This word is first recorded in the period 1950–55. Other words that entered Englishat around the same time include: Common Market, International Gothic, bleep, hot line, point spreadmethyl- is a combining form occurring in the names of chemical compounds in which the methylgroup is present. Other words that use the affix methyl- include: methylamine, methylate, methylcyclohexanol, methylheptenone, methylic
Examples of 'methyldopa' in a sentence
methyldopa
However, the effect of banana on methyldopa has not been reported.
Kiminori Mohri, Yoshihiro Uesawa 2010, 'Degradation of Methyldopa by Banana', Pharmaceuticalshttp://www.mdpi.com/1424-8247/3/3/441/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, we have investigated the impact of banana juice on methyldopa.
Kiminori Mohri, Yoshihiro Uesawa 2010, 'Degradation of Methyldopa by Banana', Pharmaceuticalshttp://www.mdpi.com/1424-8247/3/3/441/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, potential incompatibility between methyldopa and reducing excipients was evaluated using physicochemical methods.
Mohammad Reaz Siahi, Soma Rahimi, Farnaz Monajjemzadeh 2018, 'Analytical Investigation of the Possible Chemical Interaction of Methyldopa with SomeReducing Carbohydrates Used as Pharmaceutical Excipients', Advanced Pharmaceutical Bulletinhttps://apb.tbzmed.ac.ir/PDF/apb-19466. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The use of thiazides and methyldopa has declined significantly.
Eshiet UI, Yusuff KB 2014, 'Anti-hypertensive medicines prescribing for medical outpatients in a premier teachinghospital in Nigeria: a probable shift of paradigm', Pharmacy Practicehttp://www.pharmacypractice.org/journal/index.php/pp/article/view/419. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The main group treatment was nebivalol monotherapy, the control group took combined medications in different compositions (atenolol, methyldopa, nifedipin).
E V Karpova, A A Orazmuradov, I A Litvinenko, U A Andreeva, E N Kryukova, T V Bratchikova,V A Lusov 2011, 'Antihypertensive agents safety during pregnancy', RUDN Journal of Medicinehttp://journals.rudn.ru/medicine/article/view/3402. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A simple, rapid and sensitive spectrophotometric method has been developed for the determination of methyldopa in pharmaceutical formulations.
M. A. Gotardo, L. S. Lima, R. Sequinel, J. L. Rufino, L. Pezza, H. R. Pezza 2008, 'A simple spectrophotometric method for the determination of methyldopa using p-chloranilin the presence of hydrogen peroxide Um método espectrofotométrico simples para adeterminação de metildopa usando p-cloranil na presença de peróxido de hidrogênio',Eclética Químicahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000300001. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The proposed method was successfully applied to the determination of methyldopa in commercial brands of pharmaceuticals.
M. A. Gotardo, L. S. Lima, R. Sequinel, J. L. Rufino, L. Pezza, H. R. Pezza 2008, 'A simple spectrophotometric method for the determination of methyldopa using p-chloranilin the presence of hydrogen peroxide Um método espectrofotométrico simples para adeterminação de metildopa usando p-cloranil na presença de peróxido de hidrogênio',Eclética Químicahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000300001. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The methyldopachrome resulting from the oxidation of methyldopa catalyzed by peroxidase was monitored at 480 nm.
Natielle Gianine Bueno, Airton Vicente Pereira 2015, 'DETERMINAÇÃO ESPECTROFOTOMÉTRICA DE METILDOPA EM ENSAIO DE DISSOLUÇÃO DE COMPRIMIDOSUTILIZANDO EXTRATO DE RABANETE COMO FONTE DE PEROXIDASE', Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000801107&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This method can be applied for the determination of methyldopa in dissolution tests of tablets without interference from the excipients.
Natielle Gianine Bueno, Airton Vicente Pereira 2015, 'DETERMINAÇÃO ESPECTROFOTOMÉTRICA DE METILDOPA EM ENSAIO DE DISSOLUÇÃO DE COMPRIMIDOSUTILIZANDO EXTRATO DE RABANETE COMO FONTE DE PEROXIDASE', Química Novahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000801107&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Patient received methyldopa 250 mg or 500 mg, three times a day for clinical indications according a standard protocol.
Teri Wina Herwati, Yulistiani Yulistiani, Eddy Zarkaty M 2018, 'Analysis of Methyldopa Therapy on sFlt-1 Antiangiogenic Levels in Patients with SeverePreeclampsia', Folia Medica Indonesianahttps://e-journal.unair.ac.id/FMI/article/view/8052. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)