the full complement of metabolites present in a cell, tissue, or organism in a particular physiological or developmental state
Word origin
C20: from metabolite + -ome
Examples of 'metabolome' in a sentence
metabolome
Interactions were explored using a network analysis, and a metabolome profiling for specific taxa.
Patricia Velez, Laura Espinosa-Asuar, Mario Figueroa, Jaime Gasca-Pineda, Eneas Aguirre-von-Wobeser,Luis E. Eguiarte, Abril Hernandez-Monroy, Valeria Souza 2018, 'Nutrient Dependent Cross-Kingdom Interactions: Fungi and Bacteria From an OligotrophicDesert Oasis', Frontiers in Microbiologyhttps://www.frontiersin.org/article/10.3389/fmicb.2018.01755/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both obesity and ozone caused changes in the lung metabolome.
Joel Andrew Mathews, David Itiro Kasahara, Youngji Cho, Lauren Nicole Bell, PhilipRoss Gunst, Edward D. Karoly, Stephanie Ann Shore 2017, 'Effect of acute ozone exposure on the lung metabolomes of obese and lean mice', PLOS ONE10.1371/journal.pone.0181017. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Metabolome was found to be correlated with both taxonomy and activity score.
Carola Parolin, Antonella Marangoni, Luca Laghi, Claudio Foschi, Rogers Alberto ÑahuiPalomino, Natalia Calonghi, Roberto Cevenini, Beatrice Vitali 2015, 'Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity',PLOS ONE10.1371/journal.pone.0131220. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Interestingly, phytosterols were able to restore the homeostatic equilibrium of the hepatic and colonic metabolome.
Nunzia Iaccarino, Jussara Amato, Bruno Pagano, Anna Di Porzio, Matteo Micucci, LucaBolelli, Rita Aldini, Ettore Novellino, Roberta Budriesi, Antonio Randazzo 2019, 'Impact of phytosterols on liver and distal colon metabolome in experimental murinecolitis model: an explorative study', Journal of Enzyme Inhibition and Medicinal Chemistryhttp://dx.doi.org/10.1080/14756366.2019.1611802. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Approximately 30% of the plasma metabolome (235 metabolites) were significantly correlated with serum lipids.
Katherine J Li, NaNet Jenkins, Gary Luckasen, Sangeeta Rao, Elizabeth P Ryan 2018, 'Plasma metabolomics of children with aberrant serum lipids and inadequate micronutrientintake.', PLoS ONEhttp://europepmc.org/articles/PMC6209210?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, there are still major gaps in our understanding of the plant metabolome.
Sebastian eKlie, Stephan eKrueger, Leonard eKrall, Patrick eGiavalisco, Ulf-Ingo eFlügge,Lothar eWillmitzer, Dirk eSteinhauser 2011, 'Analysis of the compartmentalized metabolome – a validation of the non-aqueous fractionationtechnique', Frontiers in Plant Sciencehttp://journal.frontiersin.org/Journal/10.3389/fpls.2011.00055/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Capturing a valid snapshot of the metabolome requires rapid quenching of enzyme activities.
Rahul Vijay Kapoore, Seetharaman Vaidyanathan 2018, 'Quenching for Microalgal Metabolomics: A Case Study on the Unicellular EukaryoticGreen Alga Chlamydomonas reinhardtii', Metaboliteshttps://www.mdpi.com/2218-1989/8/4/72. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Also, this method aims to explore the impact of this stress on barley's metabolome.
Hikmat Ghosson, Adrián Schwarzenberg, Frank Jamois, Jean-Claude Yvin 2018, 'Simultaneous untargeted and targeted metabolomics profiling of underivatized primarymetabolites in sulfur-deficient barley by ultra-high performance liquid chromatography-quadrupole/time-of-flightmass spectrometry', Plant Methodshttp://link.springer.com/article/10.1186/s13007-018-0329-0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These suggest a possible contribution of mast cells to the unique metabolome of obese asthma.
Lisa G. Wood, Hashim A. Periyalil, Peter G. Gibson 2013, 'Immunometabolism in Obese Asthmatics: Are We There Yet?', Nutrientshttp://www.mdpi.com/2072-6643/5/9/3506. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)