a drug used in the treatment of leukaemia. Formula: C5H4N4S
mercaptopurine in American English
(mərˌkæptouˈpjurin)
noun
Pharmacology
a yellow, crystalline, water-insoluble powder, C5H4N4S, used in the treatment of leukemia
Word origin
[1950–55; mercapto + purine]This word is first recorded in the period 1950–55. Other words that entered Englishat around the same time include: Common Market, allograph, bleep, hot line, speech recognition
Examples of 'mercaptopurine' in a sentence
mercaptopurine
There was a poor clinical response so 5-mercaptopurine was added.
Azathioprine and 6-mercaptopurine seem to be safe in pregnancy.
A. A. Tanis 1998, 'Azathioprine in inflammatory bowel disease, a safe alternative?', Mediators of Inflammationhttp://dx.doi.org/10.1080/09629359891045. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Mercaptopurine and its derivatives are used in the treatment of leukemia.
Andrzej Czyrski, Bartłomiej Kupczyk 2013, 'The Determination of Partition Coefficient of 6-Mercaptopurine Derivatives by ThinLayer Chromatography', Journal of Chemistryhttp://dx.doi.org/10.1155/2013/419194. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Twelve patients received 6-mercaptopurine, only one (8.3%) patient had a partial response.
Ahmed Hatem Sabhan, Mazin Faisal Al-Jadiry, Hasanein Habeeb Ghali, Wisam Majeed Abed,Salma Abbas Al-Hadad 2016, 'Chronic immune thrombocytopenic purpura in children overview of 60 patients', Pediatric Hematology Oncology Journalhttp://www.sciencedirect.com/science/article/pii/S2468124516300079. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
She was on prednisone and 6-mercaptopurine.
Amporn Atsawarungruangkit, Fernando Dominguez, Gustavo Borda, Nikolaos Mavrogiorgos 2017, 'Listeria Monocytogenes Brain Abscess in Crohn's Disease Treated with Adalimumab',Case Reports in Gastroenterologyhttps://www.karger.com/Article/FullText/481165. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Azathioprine and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease.
A. A. Tanis 1998, 'Azathioprine in inflammatory bowel disease, a safe alternative?', Mediators of Inflammationhttp://dx.doi.org/10.1080/09629359891045. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
A total of 40 cases (14 paediatric) were reported (azathioprine, n = 35; 6-mercaptopurine, n = 5).
Claudia Gregoriano, Alessandro Ceschi, Christine Rauber-Lüthy, Hugo Kupferschmidt,Nicholas R. Banner, Stephan Krähenbühl, Anne B. Taegtmeyer 2014, 'Acute Thiopurine Overdose: Analysis of Reports to a National Poison Centre 1995–2013',PLoS ONE10.1371/journal.pone.0086390. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Dosing guided by pharmacogenetic testing did not show pharmacoeconomic advantage over weight-adjusted dosing of 6-mercaptopurine.
Pan SD, Zhu LL, Chen M, Xia P, Zhou Q 2016, 'Weight-based dosing in medication use: what should we know?', Patient Preference and Adherencehttps://www.dovepress.com/weight-based-dosing-in-medication-use-what-should-we-know-peer-reviewed-article-PPA. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)