a drug, mepacrine dihydrochloride, one of the first synthetic substitutes for quinine, formerly widely used to treat malaria but now largely replaced by chloroquine. Formula: C23H30ClN3O.2HCl.2H2O
US name: quinacrine
Word origin
C20: from me(thyl) + pa(ludism + a)cr(id)ine
Examples of 'mepacrine' in a sentence
mepacrine
Staining confirmed distinct myocardial regions of inflammation and fibrosis as well as mepacrine-stained platelets as the cause of intravascular thrombosis.
Tyler Spata, Daniel Bobek, Bryan A. Whitson, Sampath Parthasarathy, Peter J. Mohler,Robert S. D. Higgins, Ahmet Kilic 2013, 'A Nonthoracotomy Myocardial Infarction Model in an Ovine Using Autologous Platelets',BioMed Research Internationalhttp://dx.doi.org/10.1155/2013/938047. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Platelet degranulation was reduced upon exposure to minocycline as shown by mepacrine retention and flow cytometry.
Joseph W Jackson, Meera V Singh, Vir B Singh, Letitia D Jones, Gregory A Davidson,Sara Ture, Craig N Morrell, Giovanni Schifitto, Sanjay B Maggirwar 2016, 'Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 MitogenActivated Protein Kinase Axis.', PLoS ONEhttp://europepmc.org/articles/PMC4894566?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)