Replication-defective adenoviral vectors are an attractive alternative for gene delivery.
Matthews R James, Oliver James, Dzialo-Hatton Robin, Hurez Vincent, Weaver Casey T 2002, 'Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes ina new coxsackie/adenovirus receptor transgenic model', BMC Immunologyhttp://www.biomedcentral.com/1471-2172/3/4. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Antigenic and genotypic variants were not detected in enteric adenoviral isolates.
Serdar TUNCER, Mehmet CEYHAN, Kadriye YURDAKÖK, Güler KANRA, Şemsettin USTAÇELEBİ 1997, 'Typing of Human Adenoviruses by Restriction Endonuclease Analysis and Enteric AdenovirusInfection Rate in Children with Gastroenteritis', Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisihttp://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=1997-2-3-195-207.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants.
Saravana Kanagavelu, James M Termini, Sachin Gupta, Francesca N Raffa, Katherine AFuller, Yaelis Rivas, Sakhi Philip, Richard S Kornbluth, Geoffrey W Stone 2014, 'HIV-1 adenoviral vector vaccines expressing multi-trimeric BAFF and 4-1BBL enhanceT cell mediated anti-viral immunity.', PLoS ONEhttp://europepmc.org/articles/PMC3938597?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, adenoviral vectors and randomly inserted transgenes have several limitations.
Dmitry Akhmedov, Kavitha Rajendran, Maria G Mendoza-Rodriguez, Rebecca Berdeaux 2016, 'Knock-in Luciferase Reporter Mice for In Vivo Monitoring of CREB Activity.', PLoS ONEhttp://europepmc.org/articles/PMC4940169?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both can be blocked by adenoviral vaccination.
José Ronnie Vasconcelos, Oscar Bruña-Romero, Adriano F Araújo, Mariana R Dominguez,Jonatan Ersching, Bruna C G de Alencar, Alexandre V Machado, Ricardo T Gazzinelli,Karina R Bortoluci, Gustavo P Amarante-Mendes, Marcela F Lopes, Mauricio M Rodrigues 2012, 'Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany asuboptimal CD8+ T-cell response: reversal by adenoviral vaccine.', PLoS Pathogenshttp://europepmc.org/articles/PMC3355083?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Following complete cardiac and neurological recovery, only adenoviral genome was found in myocardial biopsy.
Ilona Lálová, Lucie Filipovská, Hana Skalická, Ondřej Šmíd, Aleš Linhart, Helena Kollárová,Jan Bělohlávek 2018, 'Refractory Ventricle Arrhythmias Alternating with Pulseless Electrical Activity ina Young Woman Rescued by Extracorporeal Cardiopulmonary Resuscitation', Case Reports in Medicinehttp://dx.doi.org/10.1155/2018/5686790. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The findings presented here promote the concept of combining adenoviral cancer vaccines with low-dose chemotherapy.
Sean M Geary, Caitlin D Lemke, David M Lubaroff, Aliasger K Salem 2013, 'The combination of a low-dose chemotherapeutic agent, 5-fluorouracil, and an adenoviraltumor vaccine has a synergistic benefit on survival in a tumor model system.', PLoS ONEhttp://europepmc.org/articles/PMC3695864?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The adenoviral vectors were released sustainingly by biodegradation, providing long-term expression of the genes.
Toshimasa Uemura and Hiroko Kojima 2011, 'Bone formation in vivo induced by Cbfa1-carrying adenoviral vectors released froma biodegradable porous β-tricalcium phosphate (β-TCP) material', Science and Technology of Advanced Materialshttp://iopscience.iop.org/1468-6996/12/3/034405. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Adenoviral replication depends on viral as well as cellular proteins.
Wilhelm Ching, Emre Koyuncu, Sonia Singh, Christina Arbelo-Roman, Barbara Hartl, ElisabethKremmer, Thomas Speiseder, Chris Meier, Thomas Dobner 2013, 'A ubiquitin-specific protease possesses a decisive role for adenovirus replicationand oncogene-mediated transformation.', PLoS Pathogenshttp://europepmc.org/articles/PMC3610741?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this review, we discuss the latest adenoviral technologies and their utilization in vaccine development.
Sam Afkhami, Yushi Yao, Zhou Xing 2016, 'Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens',Molecular Therapy: Methods & Clinical Developmenthttp://www.sciencedirect.com/science/article/pii/S2329050116301735. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)