an antihistamine, C25H27ClN2, used for treating nausea and motion sickness
Word origin
methyl benzene + chloroform + -i- + piperazine
meclizine in American English
(ˈmekləˌzin)
noun
Pharmacology
a compound, C25H27ClN2, used for preventing nausea of motion sickness, pregnancy, etc
Word origin
[1950–55; me(thylbenzene) + c(h)l(or)-2 + -i- + (pipera)zine]This word is first recorded in the period 1950–55. Other words that entered Englishat around the same time include: bleep, drip-dry, point-of-sale, speech recognition, wiretap-i- is the typical ending of the first element of compounds of Latin words, as -o- is of Greek words, but often used in English with a first element of any origin,if the second element is of Latin origin. Other words that use the affix -i- include: Frenchify, cuneiform
Seiji Kishi, Gabriela Campanholle, Vishal M. Gohil, Fabiana Perocchi, Craig R. Brooks,Ryuji Morizane, Venkata Sabbisetti, Takaharu Ichimura, Vamsi K. Mootha, Joseph V.Bonventre 2015, 'Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury',EBioMedicinehttp://www.sciencedirect.com/science/article/pii/S2352396415300876. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Protection was also seen when meclizine was administered 24 h prior to ischemia.
Seiji Kishi, Gabriela Campanholle, Vishal M. Gohil, Fabiana Perocchi, Craig R. Brooks,Ryuji Morizane, Venkata Sabbisetti, Takaharu Ichimura, Vamsi K. Mootha, Joseph V.Bonventre 2015, 'Meclizine Preconditioning Protects the Kidney Against Ischemia–Reperfusion Injury',EBioMedicinehttp://www.sciencedirect.com/science/article/pii/S2352396415300876. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Therefore, meclizine may be considered as a novel therapeutic candidate for osteoclast-related diseases.
Jiachao Guo, Weijin Li, Yingxing Wu, Xingzhi Jing, Junming Huang, Jiaming Zhang, WeiXiang, Ranyue Ren, Zhengtao Lv, Jun Xiao, Fengjing Guo 2017, 'Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partiallyby Upregulating PXR', Frontiers in Pharmacologyhttp://journal.frontiersin.org/article/10.3389/fphar.2017.00693/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)