Thalassemic patients are at risk of micronutrient deficiency.
Laila M. Sherief, Sanaa M. Abd El-Salam, Naglaa M. Kamal, Osama El safy, Mohamed A.A. Almalky, Seham F. Azab, Hemat M. Morsy, Amal F. Gharieb 2014, 'Nutritional Biomarkers in Children and Adolescents with Beta-Thalassemia-Major: AnEgyptian Center Experience', BioMed Research Internationalhttp://dx.doi.org/10.1155/2014/261761. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thalassemic erythrocytes are exposed to higher oxidative stress and lipid peroxidation.
Soleiman Mahjoub, Ahmad Tamaddoni, Maseoud Zanjanchi Nikoo, Ali Akbar Moghadamnia 2007, 'The effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemiapatients', Journal of Research in Medical Scienceshttp://journals.mui.ac.ir/jrms/article/view/1228. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The oxidation indexes were higher in erythrocytes of β-thalassemic individuals than those from normal individuals.
Alisson F. Santos, Giorgio Baldanzi, Maria Suely S. Leonart, Aguinaldo J. Nascimento 2009, 'Protective action of deferiprone and deferoxamine in erythrocytes isolated from patientswith β-thalassemias', Revista Brasileira de Hematologia e Hemoterapiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842009000600013&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Atypical presentations including carotid arteritis, aneurysm, brain abscess, and stroke occurred in the non-thalassemic patients.
Maria Nina Chitasombat, Noppadol Larbcharoensub, Ariya Chindamporn, Theerapong Krajaejun 2018, 'Clinicopathological features and outcomes of pythiosis', International Journal of Infectious Diseaseshttp://www.sciencedirect.com/science/article/pii/S1201971218300808. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No clear relationship exists between age and hematological parameters of thalassemic patients.
Mahmood Rasool, Arif Malik, Uzma Jabbar, Irshad Begum, Mahmood H. Qazi, MuhammadAsif, Muhammad I. Naseer, Shakeel A. Ansari, Jummanah Jarullah, Absarul Haque, MohammadS. Jamal 2016, 'Effect of iron overload on renal functions and oxidative stress in beta thalassemiapatients', Saudi Medical Journalhttps://www.smj.org.sa/index.php/smj/article/view/smj.2016.11.16242/9270. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The β globin gene has 3 exons and 2 introns, involved in β-thalassemic pathogenesis.
Veysel Sabri Hancer, Tunc Fisgin, Murat Buyukdogan, Ceyhun Bozkurt, Sotiraq Lako 2018, 'β globin mutations in Turkish, Northern Iraqi and Albanian patients with β thalassemiamajor', Thalassemia Reportshttps://www.pagepressjournals.org/index.php/thal/article/view/7286. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)