The low-dose metronomic treatment with cisplatin was used in anti-angiogenetic chemotherapeuticprograms.
Yun Zeng, Yang Liu, Jin Shang, Jingwen Ma, Rong Wang, Lei Deng, Youmin Guo, Fan Zhong,Mingfeng Bai, Shaojuan Zhang, Daocheng Wu 2015, 'Phosphorescence monitoring of hypoxic microenvironment in solid-tumors to evaluatechemotherapeutic effects using the hypoxia-sensitive iridium (III) coordination compound.',PLoS ONEhttp://europepmc.org/articles/PMC4365010?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most of the trials use bortezomib in combination with chemotherapeutic agents.
Mauricio Escobar, Michel Velez, Astrid Belalcazar, Edgardo S. Santos, Luis E. Raez 2011, 'The Role of Proteasome Inhibition in Nonsmall Cell Lung Cancer', Journal of Biomedicine and Biotechnologyhttp://dx.doi.org/10.1155/2011/806506. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most of the cytotoxic chemotherapeutic agents have poor aqueous solubility.
Bina Gidwani, Amber Vyas 2015, 'A Comprehensive Review on Cyclodextrin-Based Carriers for Delivery of ChemotherapeuticCytotoxic Anticancer Drugs', BioMed Research Internationalhttp://dx.doi.org/10.1155/2015/198268. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
When combined with the chemotherapeutic agent 5-fluorouracil, rapamycin was protective.
Tracey R O'Donovan, Simon Rajendran, Seamus O'Reilly, Gerald C O'Sullivan, SharonL McKenna 2015, 'Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhancesthe Efficacy of Therapeutic Agents In Vitro and In Vivo.', PLoS ONEhttp://europepmc.org/articles/PMC4527721?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This renders them difficult, sometimes impossible, to treat using conventional chemotherapeutic agents.
Mahmoud Y Alkawareek, Qais Th Algwari, Garry Laverty, Sean P Gorman, William G Graham,Deborah O'Connell, Brendan F Gilmore 2012, 'Eradication of Pseudomonas aeruginosa biofilms by atmospheric pressure non-thermalplasma.', PLoS ONEhttp://europepmc.org/articles/PMC3432087?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The oncogenic cytoplasmic p21 contributes to cancer aggressiveness and chemotherapeutic failure.
Arnatchai Maiuthed, Chuanpit Ninsontia, Katharina Erlenbach-Wuensch, Benardina Ndreshkjana,Julienne K. Muenzner, Aylin Caliskan, Husayn Ahmed P., Chatchai Chaotham, Arndt Hartmann,Adriana Vial Roehe, Vijayalakshmi Mahadevan, Pithi Chanvorachote, Regine Schneider-Stock 2018, 'Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2',Cancershttp://www.mdpi.com/2072-6694/10/10/373. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The chemotherapeutic treatment was administered to four patients (50%) following surgery without major side effects.
Montassar Ghalleb, Hatem Bouzaiene, Sarah Seghaier, Hanen Bouaziz, Monia Hechiche,Riadh Chargui, Rahal Khaled 2019, 'Fertility sparing surgery for stage Ic ovarian cancer: An eight case series', Journal of Clinical and Investigative Surgeryhttps://www.e-repository.org/jcis/4.1/32.37.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Digoxin, a cardiac glycoside, has recently been suggested to be a novel chemotherapeutic agent.
Sheng-Yi Lin, Hsiu-Hui Chang, Yi-Hua Lai, Ching-Hsiung Lin, Min-Hsuan Chen, Gee-ChenChang, Meng-Feng Tsai, Jeremy J. W. Chen 2015, 'Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related SignalingPathways in Non-Small Cell Lung Cancer', PLOS ONE10.1371/journal.pone.0123305. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Microtubule-targeting small molecules are chemotherapeutic agents that are widelyused in the treatment of cancer.
Luma G. Magalhaes, Fernando B. Marques, Marina B. da Fonseca, Kamilla R. Rogério,Cedric S. Graebin, Adriano D. Andricopulo 2016, 'Discovery of a Series of Acridinones as Mechanism-Based Tubulin Assembly Inhibitorswith Anticancer Activity', PLOS ONE10.1371/journal.pone.0160842. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In vitro and in vivo tumorigenicity was evaluated and the sensitivity against chemotherapeutic agents assessed.
Andreas Krieg, Sabrina Mersch, Inga Boeck, Levent Dizdar, Eberhard Weihe, Zena Hilal,Markus Krausch, Birte Möhlendick, Stefan A. Topp, Roland P. Piekorz, Wolfgang Huckenbeck,Nikolas H. Stoecklein, Martin Anlauf, Wolfram T. Knoefel 2014, 'New Model for Gastroenteropancreatic Large-Cell Neuroendocrine Carcinoma: Establishmentof Two Clinically Relevant Cell Lines', PLoS ONE10.1371/journal.pone.0088713. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)