Growth factor pulses induced modest phase delays in unshocked, but not serum-shocked, organoids.
Sean R. Moore, Jill Pruszka, Jefferson Vallance, Eitaro Aihara, Toru Matsuura, MarshallH. Montrose, Noah F. Shroyer, Christian I. Hong 2014, 'Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse smallintestine', Disease Models & Mechanismshttp://dmm.biologists.org/content/7/9/1123. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Remarkably, unshocked organoids autonomously synchronized rhythms within 12 hours of recording.
Sean R. Moore, Jill Pruszka, Jefferson Vallance, Eitaro Aihara, Toru Matsuura, MarshallH. Montrose, Noah F. Shroyer, Christian I. Hong 2014, 'Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse smallintestine', Disease Models & Mechanismshttp://dmm.biologists.org/content/7/9/1123. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)