the production or induction of malformations or monstrosities, esp. of a developing embryo or fetus
Also called: teratogeny (ˌterəˈtɑdʒəni), teratogenicity (təˌrætoudʒəˈnɪsɪti, ˌterətou-)
Derived forms
teratogenetic (təˌrætoudʒəˈnetɪk, ˌterətou-)
adjective
Word origin
[1900–05; terato- + -genesis]This word is first recorded in the period 1900–05. Other words that entered Englishat around the same time include: cathode-ray tube, elder statesman, hormone, internship, throwaway
Examples of 'teratogenesis' in a sentence
teratogenesis
In general, targeted therapies are contraindicated during pregnancy due to concerns about teratogenesis.
Jorine de Haan, Johannes V. van Thienen, Michael Casaer, Rebekka A. Hannivoort, KristelVan Calsteren, Minke van Tuyl, Mathilde M. van Gerwen, Anne Debeer, Frédéric Amant,Rebecca C. Painter 2018, 'Severe Adverse Reaction to Vemurafenib in a Pregnant Woman with Metastatic Melanoma',Case Reports in Oncologyhttps://www.karger.com/Article/FullText/487128. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Species with minimal (less than 1.5%) and the maximum inclination to teratogenesis (≤ 3.5%) were identified.
Anna Ivashchenko 2014, 'Quantitative indicators of teratological variability of Kazakhstan tulips in natureand in culture', Modern Phytomorphologyhttp://phytomorphology.org/PDF/MP6/06151154.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These data collectively advance a mechanistic hypothesis for teratogenesis leading to microencephaly.
Joseph D Tingling, Shameena Bake, Rhonda Holgate, Jeremy Rawlings, Phillips P Nagsuk,Jayashree Chandrasekharan, Sarah L Schneider, Rajesh C Miranda 2013, 'CD24 expression identifies teratogen-sensitive fetal neural stem cell subpopulations:evidence from developmental ethanol exposure and orthotopic cell transfer models.',PLoS ONEhttp://europepmc.org/articles/PMC3718834?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Exposure to pro-oxidants during this period can be deleterious, resulting in altered physiology, teratogenesis, later-life diseases, or lethality.
Karilyn E. Sant, Jason M. Hansen, Larissa M. Williams, Nancy L. Tran, Jared V. Goldstone,John J. Stegeman, Mark E. Hahn, Alicia Timme-Laragy 2017, 'The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in thedeveloping zebrafish embryo', Redox Biologyhttp://www.sciencedirect.com/science/article/pii/S2213231717302409. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This review emphasizes the necessity to consider hyperglycemia-induced teratogenesis during genetic counseling of parents with prenatally detected fetal malformations.
Chih-Ping Chen 2005, 'Congenital Malformations Associated with Maternal Diabetes', Taiwanese Journal of Obstetrics & Gynecologyhttp://www.sciencedirect.com/science/article/pii/S1028455909600991. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)