We designed a rigidified ligand, which showed unfavorable experimental binding affinity due to weakened enthalpy.
Wanli You, Yu-Ming M Huang, Smitha Kizhake, Amarnath Natarajan, Chia-En A Chang 2016, 'Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and InhibitorDesign.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC4999267?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Administrators responded with control strategies that rigidified organizations, forestalling dialog and learning processes.
Heinrich Mintrop 2003, 'The Limits of Sanctions in Low-Performing Schools', Education Policy Analysis Archiveshttp://epaa.asu.edu/ojs/article/view/231. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)