Our results suggest that rigidification may be just one of many biophysical mechanisms for increasing affinity.
Jeliazko R. Jeliazkov, Adnan Sljoka, Daisuke Kuroda, Daisuke Kuroda, Nobuyuki Tsuchimura,Naoki Katoh, Kouhei Tsumoto, Kouhei Tsumoto, Jeffrey J. Gray, Jeffrey J. Gray, JeffreyJ. Gray, Jeffrey J. Gray 2018, 'Repertoire Analysis of Antibody CDR-H3 Loops Suggests Affinity Maturation Does NotTypically Result in Rigidification', Frontiers in Immunologyhttp://journal.frontiersin.org/article/10.3389/fimmu.2018.00413/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The co-evolutionary mechanisms include antibody binding angle maturation, gradual loop rigidification, surface charge modulation, and changes in glycan contacts.
Kimmo Rantalainen, Zachary T. Berndsen, Sasha Murrell, Liwei Cao, Oluwarotimi Omorodion,Jonathan L. Torres, Mengyu Wu, Jeffrey Umotoy, Jeffrey Copps, Pascal Poignard, EliseLandais, James C. Paulson, Ian A. Wilson, Andrew B. Ward 2018, 'Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage ProvidesBenchmarks for Vaccine Design', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124718307927. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)