The results of proliferation assay and colony formation assay showed the antigrowth effect of sirtinol.
Yao Fong, Yin-Chieh Lin, Chang-Yi Wu, Hui-Min David Wang, Li-Li Lin, Han Lin Chou,Yen-Ni Teng, Shyng-Shiou Yuan, Chien-Chih Chiu 2014, 'The Antiproliferative and Apoptotic Effects of Sirtinol, a Sirtuin Inhibitor on HumanLung Cancer Cells by Modulating Akt/β-Catenin-Foxo3A Axis', The Scientific World Journalhttp://dx.doi.org/10.1155/2014/937051. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Its antigrowth effect seems to involve the blockage of autophagic process as well.
Buse Cevatemre, Konstantinos Dimas, Bruno Botta, Engin Ulukaya 2017, 'Pristimerin is a Promising Natural Product against Breast Cancer in vitro and in vivothrough Apoptosis and the Blockage of Autophagic Flux', Proceedingshttps://www.mdpi.com/2504-3900/1/10/973. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)