the introduction of a carbonyl group into a compound through chemical reaction
Examples of 'carbonylation' in a sentence
carbonylation
Furthermore, we demonstrate that living tardigrade can accumulate carbonylation.
Mira Kuzmic, Myriam Richaud, Pierre Cuq, Sandrine Frelon, Simon Galas 2018, 'Carbonylation accumulation of the Hypsibius exemplaris anhydrobiote reveals age-associatedmarks', PLOS ONE10.1371/journal.pone.0208617. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here we investigated radiation effects on protein carbonylation, a primary marker for protein oxidative damage.
Yong-Chul Kim, Michal Barshishat-Kupper, Elizabeth A. McCart, Gregory P. Mueller,Regina M. Day 2014, 'Bone Marrow Protein Oxidation in Response to Ionizing Radiation in C57BL/6J Mice',Proteomeshttp://www.mdpi.com/2227-7382/2/3/291. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
For reasons unknown, only some proteins are prone to carbonylation.
Etienne Maisonneuve, Adrien Ducret, Pierre Khoueiry, Sabrina Lignon, Sonia Longhi,Emmanuel Talla, Sam Dukan 2009, 'Rules governing selective protein carbonylation.', PLoS ONEhttp://europepmc.org/articles/PMC2751825?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Total antioxidant capacity, lipid peroxidation, protein carbonylation, and total thiol content were measured.
José Claudio Fonseca Moreira, Magnus Benetti, Luciano Acordi da Silva, Mariana LeivasMüller Hoff, Cleber Aurino Pinho, Débora da Luz Scheffer, Ricardo Aurino Pinho 2012, ' Impact of ironman triathlon on oxidative stress Parameters', Revista Brasileira de Cineantropometria e Desempenho Humanohttps://periodicos.ufsc.br/index.php/rbcdh/article/view/1980-0037.2012v14n2p174/20991. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Immunocytochemical studies also revealed a temporal/spatial relationship between carbonylation and cellular apoptosis.
Anushka Dasgupta, Jianzheng Zheng, Oscar A. Bizzozero 2012, 'Protein Carbonylation and Aggregation Precede Neuronal Apoptosis Induced by PartialGlutathione Depletion', ASN Neurohttps://doi.org/10.1042/AN20110064. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Protein carbonylation was only transiently augmented pointing to an effective antioxidant defense in these cells.
Cheryl S. Sultan, Andrea Saackel, Antonia Stank, Thomas Fleming, Maria Fedorova, RalfHoffmann, Rebecca C. Wade, Markus Hecker, Andreas H. Wagner 2018, 'Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemicendothelial cells', Redox Biologyhttp://www.sciencedirect.com/science/article/pii/S2213231718300533. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Furthermore, it led to reduced carbonylation of proteins in both glycerol and trehalose loaded cells.
Noha A S Alotaibi, Nigel K H Slater, Hassan Rahmoune 2016, 'Salidroside as a Novel Protective Agent to Improve Red Blood Cell Cryopreservation.',PLoS ONEhttp://europepmc.org/articles/PMC5025239?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The presence of a carbonylated site rendered the neighbouring carbonylatable site more prone to carbonylation.
Etienne Maisonneuve, Adrien Ducret, Pierre Khoueiry, Sabrina Lignon, Sonia Longhi,Emmanuel Talla, Sam Dukan 2009, 'Rules governing selective protein carbonylation.', PLoS ONEhttp://europepmc.org/articles/PMC2751825?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We also show a temporal correlation between protein carbonylation (but not oxidative stress) and apoptosis.
Anushka Dasgupta, Jianzheng Zheng, Nora I. Perrone-Bizzozero, Oscar A. Bizzozero 2013, 'Increased Carbonylation, Protein Aggregation and Apoptosis in the Spinal Cord of Micewith Experimental Autoimmune Encephalomyelitis', ASN Neurohttps://doi.org/10.1042/AN20120088. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Protein carbonylation in hyperlipidemic group were higher than controls (p< 0.01).
Hande BAYAMLIOĞLU, Aymelek GÖNENÇ, Erdal DURU, Funda BIYIKOĞLU 2012, 'EVALUATION OF THE RELATIONSHIP BETWEEN SERUM ADIPONECTIN LEVELS AND OXIDATIVE STRESS,PROINFLAMMATORY CYTOKINES IN HYPERLIPIDEMIA', Turkish Journal of Pharmaceutical Scienceshttp://www.turkjps.org/archives/archive-detail/article-preview/evaluaton-of-the-relatonshp-between-serum-adponect/12424. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)