Studies evaluating the association of canities with osteopenia and cardiovascular disease have revealed mixed results.
Deepika Pandhi, Deepshikha Khanna 2013, 'Premature graying of hair', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=2013;volume=79;issue=5;spage=641;epage=653;aulast=Pandhi. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Diagnosis of premature canities was made based on clinical examination.
Putri Ashraf, Nelva K Jusuf, Rointan Simanungkalit 2018, 'Association between premature canities and quality of life at Medan, Indonesia 2017',Bali Medical Journalhttps://balimedicaljournal.org/index.php/bmj/article/view/1007. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Premature canities may occur alone as an autosomal dominant condition or in association with various autoimmune or premature aging syndromes.
Deepika Pandhi, Deepshikha Khanna 2013, 'Premature graying of hair', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=2013;volume=79;issue=5;spage=641;epage=653;aulast=Pandhi. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)