[1655–65; anti- + febrile]This word is first recorded in the period 1655–65. Other words that entered Englishat around the same time include: contour, grille, intensity, outline, riskanti- is a prefix meaning “against,” “opposite of,” “antiparticle of,” used in the formationof compound words (anticline); used freely in combination with elements of any origin (antibody; antifreeze; antiknock; antilepton)