a three-base unit of genetic code contained in transfer RNA that corresponds to a codon region on messenger RNA, involved in genetic translation
Examples of 'anticodon' in a sentence
anticodon
We then review interdependent anticodon loop modifications involving position 37 in eukaryotes.
Richard J. Maraia, Aneeshkumar G. Arimbasseri 2017, 'Factors That Shape Eukaryotic tRNAomes: Processing, Modification and Anticodon–Codon Use',Biomoleculeshttp://www.mdpi.com/2218-273X/7/1/26. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Anticodon breakage inhibits protein synthesis, which, in turn, results in growth arrest or cell death.
Anupam K. Chakravarty, Paul Smith, Radhika Jalan, Stewart Shuman 2014, 'Structure, Mechanism, and Specificity of a Eukaryal tRNA Restriction Enzyme Involvedin Self-Nonself Discrimination', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124714002125. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Consequently, several yeast mutants lacking important anticodon loop modifications were shown to accumulate protein aggregates.
Alexander Bruch, Roland Klassen, Raffael Schaffrath 2018, 'Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications', Geneshttps://www.mdpi.com/2073-4425/9/11/516. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Thus, ψ38/39 may protect the anticodon loop configuration from disturbances by loss of other modifications or base changes.
Roland Klassen, Raffael Schaffrath 2017, 'Role of Pseudouridine Formation by Deg1 for Functionality of Two Glutamine IsoacceptortRNAs', Biomoleculeshttp://www.mdpi.com/2218-273X/7/1/8. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Modifications at these positions determine the quality of codon-anticodon pairing and the speed of translation on the ribosome.
Ya-Ming Hou, Isao Masuda, Howard Gamper 2019, 'Codon-Specific Translation by m1G37 Methylation of tRNA', Frontiers in Geneticshttps://www.frontiersin.org/article/10.3389/fgene.2018.00713/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Water molecules located in the present structure were involved in the stabilization of two alternative conformations of the anticodon stem-loop.
Oleg M Ganichkin, Ekaterina A Anedchenko, Markus C Wahl 2011, 'Crystal structure analysis reveals functional flexibility in the selenocysteine-specifictRNA from mouse.', PLoS ONEhttp://europepmc.org/articles/PMC3101227?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)