The retinotectal innervation appeared significantly reduced at 10 days (55.7%) anddid not progress further up to 14 weeks (46.6%).
Francisco J. Valiente-Soriano, Manuel Salinas-Navarro, Manuel Jiménez-López, LuisAlarcón-Martínez, Arturo Ortín-Martínez, José M. Bernal-Garro, Marcelino Avilés-Trigueros,Marta Agudo-Barriuso, María P. Villegas-Pérez, Manuel Vidal-Sanz 2015, 'Effects of Ocular Hypertension in the Visual System of Pigmented Mice', PLOS ONE10.1371/journal.pone.0121134. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
I addressed this issue in the case of the ordered axonal projections called topographic maps in the retinotectal system.
Honda Naoki 2017, 'Revisiting chemoaffinity theory: Chemotactic implementation of topographic axonalprojection.', PLoS Computational Biologyhttp://europepmc.org/articles/PMC5562328?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
At the onset of retinotectal connections, intact larvae showed major changes in the spatiotemporal structure of spontaneous activity.
Thomas Pietri, Sebastián A. Romano, Verónica Pérez-Schuster, Jonathan Boulanger-Weill,Virginie Candat, Germán Sumbre 2017, 'The Emergence of the Spatial Structure of Tectal Spontaneous Activity Is Independentof Visual Inputs', Cell Reportshttp://www.sciencedirect.com/science/article/pii/S2211124717304904. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Although rb1 mutants eventually establish basic retinotectal connectivity, behavioral analysis reveals that mutants exhibit deficits in distinct, visually guided behaviors.
Michael Gyda, Marc Wolman, Kristin Lorent, Michael Granato 2012, 'The tumor suppressor gene retinoblastoma-1 is required for retinotectal developmentand visual function in zebrafish.', PLoS Geneticshttp://europepmc.org/articles/PMC3510048?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Despite its clinical relevance, the roles of rb1 during normal retinotectal development and function are not well understood.
Michael Gyda, Marc Wolman, Kristin Lorent, Michael Granato 2012, 'The tumor suppressor gene retinoblastoma-1 is required for retinotectal developmentand visual function in zebrafish.', PLoS Geneticshttp://europepmc.org/articles/PMC3510048?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)