the synthesis of fatty acids in the body from glucose and other substrates
Examples of 'lipogenesis' in a sentence
lipogenesis
Glucose consumption, metabolite efflux and gene expression of glycolytic and lipogenesis-related genes were measured.
Floriana Rotondo, Ana Cecilia Ho-Palma, Xavier Remesar, José Antonio Fernández-López,María del Mar Romero, Marià Alemany 2018, 'Effect of sex on glucose handling by adipocytes isolated from rat subcutaneous, mesentericand perigonadal adipose tissue', PeerJhttps://peerj.com/articles/5440.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Across adipocyte differentiation, lipogenesis increased whilst β-oxidation decreased.
Laura L. Gathercole, Stuart A. Morgan, Iwona J. Bujalska, David Hauton, Paul M. Stewart,Jeremy W. Tomlinson 2011, 'Regulation of Lipogenesis by Glucocorticoids and Insulin in Human Adipose Tissue',PLoS ONE10.1371/journal.pone.0026223. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Consumption of large amounts of fructose or sucrose increases lipogenesis and circulating triglycerides in humans.
Kristin M. Hirahatake, John K. Meissen, Oliver Fiehn, Sean H. Adams 2011, 'Comparative Effects of Fructose and Glucose on Lipogenic Gene Expression and IntermediaryMetabolism in HepG2 Liver Cells', PLoS ONE10.1371/journal.pone.0026583. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Previous studies demonstrated that these food components reduced serum cholesterol levels and suppressed hepatic lipogenesis.
Yoko Takahashi, Tomokazu Konishi, Kohji Yamaki 2019, 'Tofu and fish oil independently modulate serum lipid profiles in rats: Analyses of10 class lipoprotein profiles and the global hepatic transcriptome', PLOS ONE10.1371/journal.pone.0210950. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In conclusion, fructose increases de novo lipogenesis, reduces the antioxidant defenses, and diminishes mitochondrial biogenesis.
Iara Karise, Fernanda Ornellas, Sandra Barbosa-da-Silva, Cristiane Matsuura, Marianodel Sol, Marcia Barbosa Aguila, Carlos A. Mandarim-de-Lacerda 2017, 'Liver and Metformin: Lessons of a fructose diet in mice', Biochimie Openhttp://www.sciencedirect.com/science/article/pii/S2214008516300165. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
About 20–30% of triglycerides are synthesized via de novo lipogenesis.
Xian Yu, Lu-Ping Ren, Chao Wang, Ya-Jun Zhu, Han-Ying Xing, Jing Zhao, Guang-Yao Song 2018, 'Role of X-Box Binding Protein-1 in Fructose-Induced De Novo Lipogenesis in HepG2 Cells',Chinese Medical Journalhttp://www.cmj.org/article.asp?issn=0366-6999;year=2018;volume=131;issue=19;spage=2310;epage=2319;aulast=Yu. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The gene expressions of hepatic lipogenesis were also studied.
Urarat Nanna, Jarinyaporn Naowaboot, Linda Chularojmontri, Pholawat Tingpej, SuvaraWattanapitayakul 2019, 'Effects of Brassica oleracea extract on impaired glucose and lipid homeostasis inhigh-fat diet-induced obese mice', Asian Pacific Journal of Tropical Biomedicinehttp://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=2;spage=80;epage=84;aulast=Nanna. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Major lipids were profiled to confirm the products predicted in the lipogenesis pathway.
Lei Wang, Wei Chen, Yun Feng, Yan Ren, Zhennan Gu, Haiqin Chen, Hongchao Wang, MichaelJ Thomas, Baixi Zhang, Isabelle M Berquin, Yang Li, Jiansheng Wu, Huanxin Zhang, YuandaSong, Xiang Liu, James S Norris, Suriguga Wang, Peng Du, Junguo Shen, Na Wang, YanlinYang, Wei Wang, Lu Feng, Colin Ratledge, Hao Zhang, Yong Q Chen 2011, 'Genome characterization of the oleaginous fungus Mortierella alpina.', PLoS ONEhttp://europepmc.org/articles/PMC3234268?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Besides, it also helps to enhance fat oxidation while reducing de novo lipogenesis.
Li Oon Chuah, Wan Yong Ho, Boon Kee Beh, Swee Keong Yeap 2013, 'Updates on Antiobesity Effect of Garcinia Origin (−)-HCA', Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2013/751658. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, the intricate nature of lipogenesis has impeded metabolic engineering.
Xiang Wang, Hong-Po Dong, Wei Wei, Srinivasan Balamurugan, Wei-Dong Yang, Jie-ShengLiu, Hong-Ye Li 2018, 'Dual expression of plastidial GPAT1 and LPAT1 regulates triacylglycerol productionand the fatty acid profile in Phaeodactylum tricornutum', Biotechnology for Biofuelshttp://link.springer.com/article/10.1186/s13068-018-1317-3. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)