All the reactions proceed via two transitions and include two consecutive steps: bimolecular and unimolecular.
Abdulfatai Siaka, Adamu Uzairu, Sulaiman Idris, Hamza Abba 2016, 'DFT (B3LYP) COMPUTATIONAL STUDY ON THE MECHANISMS OF FORMATION OF SOME SEMICARBAZONES',Chemistry Journal of Moldova: General, Industrial and Ecological Chemistryhttp://www.cjm.asm.md/sites/default/files/article_files/ChemJMold201611(1)_74-85_Siaka.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Concerted mechanisms are predominant as compared with homolytic mechanisms throughout unimolecular decomposition pathways.
Xiaoyan Jiang, Qiang Lu, Bin Hu, Ji Liu, Changqing Dong, Yongping Yang 2017, 'A Comprehensive Study on Pyrolysis Mechanism of Substituted β-O-4 Type Lignin Dimers',International Journal of Molecular Scienceshttps://www.mdpi.com/1422-0067/18/11/2364. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Dissipative particle dynamics simulation showed that core-mesophere-shell-type unimolecular micelles could be formed.
Wenjing Lin, Na Yao, Hongru Li, Samuel Hanson, Wenqing Han, Chun Wang, Lijuan Zhang 2016, 'Co-Delivery of Imiquimod and Plasmid DNA via an Amphiphilic pH-Responsive Star Polymerthat Forms Unimolecular Micelles in Water', Polymershttp://www.mdpi.com/2073-4360/8/11/397. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The following step, unimolecular elimination of water, also presents a very high activation free energy.
Pliego Jr. Josefredo R., Alcântara Antônio Flávio de C., Veloso Dorila Piló, AlmeidaWagner B. de 1999, 'Theoretical and experimental investigation of the formation of E- and Z-Aldiminesfrom the reaction of methylamine with acetaldehyde', Journal of the Brazilian Chemical Societyhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531999000500008. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The unimolecular pentavalent vaccine construct was shown to be safe and immunogenic.
Roisin E. O’Cearbhaill, Govind Ragupathi, Jianglong Zhu, Qian Wan, Svetlana Mironov,Guangbin Yang, Maria K. Spassova, Alexia Iasonos, Sara Kravetz, Ouathek Ouerfelli,David R. Spriggs, Samuel J. Danishefsky, Paul J. Sabbatini 2016, 'A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization ofPatients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission',Cancershttp://www.mdpi.com/2072-6694/8/4/46. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The variant target oligonucleotides were annealed and ligated with the constant oligonucleotides to form the new unimolecular oligonucleotides for microspotting.
Zuhong Lu, Yi Zhu, Yunfei Bai, Tongxiang Li, Jinke Wang 2003, 'Fabrication of Unimolecular Double-stranded DNA Microarrays on Solid Surfaces forProbing DNA-Protein/Drug Interactions', Moleculeshttp://www.mdpi.com/1420-3049/8/1/153/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Two unimolecular reactions have been investigated.
Anatoly V. Stepanov, Maxim A. Stepanov 2017, 'Information Entropy of Molecular Tunneling', Proceedingshttps://www.mdpi.com/2504-3900/2/4/151. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The physical meaning of information entropy for low-temperature plateau of unimolecular chemical reaction has been determined.
Anatoly V. Stepanov, Maxim A. Stepanov 2017, 'Information Entropy of Molecular Tunneling', Proceedingshttps://www.mdpi.com/2504-3900/2/4/151. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Multi-arm copolymers with a dendritic core, as well as hyperbranched and comb-like polymers, can form unimolecular micelles easily.
Stefania Ordanini, Francesco Cellesi 2018, 'Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation,Characterization and Drug Nanoencapsulation', Pharmaceuticshttps://www.mdpi.com/1999-4923/10/4/209. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)