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单词 kinetochore
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kinetochore

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Examples of 'kinetochore' in a sentence
kinetochore

The centromere, on which kinetochore proteins assemble, ensures precise chromosome segregation.Centromeres, sites of kinetochore assembly, are important for chromosome stability and integrity.In contrast, budding yeast has a specific 125 bp sequence required for kinetochore function.The factors determining the dynamics of kinetochore clustering remain largely unknown.Thus, we propose an unexpected relationship between inner kinetochore organization and spindle integrity.We found that the initiation of spindle assembly results from chromosome-microtubule interactions that are kinetochore-independent.As such this provides the first functional evidence for a monopolin-binding site at the kinetochore.The budding yeast kinetochore comprises more than 60 different proteins.Although merotelic attachments are common early in mitosis, some escape detection by the kinetochore pathway.Erroneous kinetochore assembly or activity produces aneuploid cells that contain an abnormal number of chromosomes.
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